胰高血糖素氢氯化物(人)

胰高血糖素氢氯化物(人)用途

胰高血糖素对蛋白质和氨基酸代谢有显著影响。胰高血糖素抑制氨基酸并入肝脏、肌肉和胰腺的蛋白质,以增加氮的排泄,促进肝脏尿素合成,并增加肝脏转氨酶和尿素循环酶的浓度。胰高血糖素可以促进肝脏对氨基酸的摄取,增强其与肝糖原的结合,并降低血液中氨基酸的浓度[1]。

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胰高血糖素氢氯化物(人)名称

[ CAS 号 ]:
9007-92-5

[ 中文名 ]:
胰高血糖素

[ 英文名 ]:
Glucagon

[中文别名 ]:

胰高血糖素氢氯化物(人)

[英文别名 ]:

Glucagon hydrochloride
Glucagonoid
Hyperglycemic-glycogenolytic factor
glukagonnovo
Glucagon RecoMbinant
Glukagon
MFCD00167532
HG-Factor

胰高血糖素氢氯化物(人)生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Bromer WW, Chance RE. Zinc glucagon depression of blood amino acids in rabbits. Diabetes. 1969 Nov;18(11):748-54.

胰高血糖素氢氯化物(人)物理化学性质

[ 沸点 ]:
230ºC at 760 mm Hg

[ 熔点 ]:
-15ºC

[ 分子式 ]:
C₁₅₃H₂₂₆ClN₄₃O₄₉S

[ 分子量 ]:
3519.21000

[ 精确质量 ]:
3516.59000

[ PSA ]:
1564.04000

[ LogP ]:
0.39110

[ 外观性状 ]:
powder

[ 储存条件 ]:
2-8°C

胰高血糖素氢氯化物(人)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ3980000

CHEMICAL NAME :: Glucagon

CAS REGISTRY NUMBER :: 9007-92-5

LAST UPDATED :: 199704

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C151-H224-N42-O50-S

MOLECULAR WEIGHT :: 3460.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 mg/kg/4W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - hyperglycemia Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 140 mg/kg/4W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3600 ug/kg

SEX/DURATION :: female 16-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 75 mg/L

REFERENCE :: EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 34,474,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83978 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 825 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83978 No. of Facilities: 109 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 11153 (estimated) No. of Female Employees: 9781 (estimated)

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胰高血糖素氢氯化物(人)安全信息

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LZ3980000

胰高血糖素氢氯化物(人)文献

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Glucagon secretion after metabolic surgery in diabetic rodents.

J. Endocrinol. 223(3) , 255-65, (2014)

Excessive or inadequate glucagon secretion promoting hepatic gluconeogenesis and glycogenolysis is believed to contribute to hyperglycemia in patients with type 2 diabetes. Currently, metabolic surger...

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