LEUKOTRIENE A4 HYDROLASE (HUMAN RECOMBINANT)

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Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.

Mol. Pharmacol. 89 , 413-24, (2016)

Angiotensin IV (Ang IV) and related peptide analogs, as well as nonpeptide inhibitors of insulin-regulated aminopeptidase (IRAP), have previously been shown to enhance memory and cognition in animal m...

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness.

Am. J. Respir. Crit. Care Med. 181 , 899-907, (2010)

Allergic asthma is characterized by reversible airway obstruction, lung inflammation, and airway hyperresponsiveness (AHR). Previous studies using leukotriene B(4) (LTB(4)) receptor 1-deficient mice a...

Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema.

J. Immunol. 192(11) , 5059-68, (2014)

The leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme with epoxy hydrolase and aminopeptidase activities. We hypothesize that the LTA4H aminopeptidase activity alleviates neutrophilic inflamma...

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