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酰化酶

酰化酶用途

氨基酰化酶(酰化酶I)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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酰化酶名称

[ CAS 号 ]:
9012-37-7

[ 中文名 ]:
氨基酰化酶

[ 英文名 ]:
Native Aspergillus melleus Acylase I

[中文别名 ]:

[英文别名 ]:

E.C. 3.5.1.14
N-Acyl-L-amino acid amidohydrolase
Hippuricase
Benzamidase
Dehydropeptidase II
Aminoacylase I
Histozyme
Hippurase
L-Aminoacylase
Amino acid deacylase

酰化酶生物活性

[ 描述 ]:

氨基酰化酶(酰化酶I)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

酰化酶物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
813.3±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₀H₃₄Cl₂N₄O

[ 分子量 ]:
537.523

[ 闪点 ]:
445.7±34.3 °C

[ 精确质量 ]:
536.210938

[ LogP ]:
7.64

[ 外观性状 ]:
固体;White to Amber powder to crystalline

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.668

[ 储存条件 ]:
<0°C;避免加热

酰化酶安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H334-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
36/37/38-42

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BF4890000

酰化酶制备

以猪肾、淀粉酶或米曲霉为原料，经匀浆、离心去沉淀后，用硫酸铵分级沉淀，经水透析、离心后得粗酶液，再分别用丙酮、乙醇分级沉淀、DEAE-纤维素柱层析纯化后得产品。

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酰化酶文献

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity.

Biochem. J. 451(2) , 217-26, (2013)

The crystal structure of the wild-type form of glutaryl-7-ACA (7-aminocephalosporanic acid) acylase from Pseudomonas N176 and a double mutant of the protein (H57βS/H70βS) that displays enhanced cataly...

Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration.

Xenobiotica 45 , 811-9, (2015)

1. Bisphenol AF (BPAF) is used as a crosslinking agent for polymers and is being considered as a replacement for bisphenol A (BPA). 2. In this study, comparative clearance and metabolism of BPAF and B...

Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase.

J. Biol. Chem. 201(2) , 847-56, (1953)

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酰化酶