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羧肽酶B(猪胰)

羧肽酶B(猪胰)用途

羧肽酶B是一种能特异性降解肽链的肽外切酶。羧肽酶B从C端逐渐降解以释放游离氨基酸。羧肽酶B仅水解与碱性氨基酸(如精氨酸和赖氨酸)作为C末端残基的肽键[1][2]。

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羧肽酶B(猪胰)名称

[ CAS 号 ]:
9025-24-5

[ 中文名 ]:
羧肽酶B

[ 英文名 ]:
Carboxypeptidase B

[中文别名 ]:

羧肽酶 B

[英文别名 ]:

Protaminase
Peptidyl-L-lysine(L-arginine) hydrolase
Carboxypeptidase B from human pancreas
Protaminase,AEBSF treated
Carboxypeptidase B from porcine pancreas

羧肽酶B(猪胰)生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. FOLK JE, et al. The kinetics of carboxypeptidase B activity. II. Kinetic parameters of the cobalt and cadmium enzymes. J Biol Chem. 1962 Oct;237:3100-4.

[2]. Qian X, et al. Molecular characterization of carboxypeptidase B-like (CPB) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunol. 2019 Nov;94:434-446.

羧肽酶B(猪胰)物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
966.7±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₁H₃₈N₄O₇S

[ 分子量 ]:
610.721

[ 闪点 ]:
538.4±34.3 °C

[ 精确质量 ]:
610.246094

[ PSA ]:
197.75000

[ LogP ]:
3.26

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.595

[ 储存条件 ]:
−20°C

羧肽酶B(猪胰)MSDS

详细MSDS(安全技术说明书)

羧肽酶B(猪胰)安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H334-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

羧肽酶B(猪胰)文献

Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B.

Biotechnol. Prog. 25(4) , 1064-70, (2009)

Insulin is a polypeptide hormone which is produced by the beta-cell of pancreas and controls the blood glucose level in the human body. Enzymatic modification of human proinsulin using trypsin and car...

Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: First insights from steered molecular dynamics simulations

J. Mol. Graph. Model. 38 , 298-303, (2012)

Graphical abstract

Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.

J. Med. Chem. 56(19) , 7527-35, (2013)

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) is a zinc-containing carboxypeptidase and significantly inhibits fibrinolysis. TAFIa inhibitors are thus expected to act as profibrinolyti...

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