羧甲基纤维素钙
羧甲基纤维素钙用途
羧甲基纤维素钙可用作赋形剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。
点击显示
羧甲基纤维素钙名称
[ CAS 号 ]:
9050-04-8
[ 中文名 ]:
羧甲基纤维素钙
[ 英文名 ]:
carboxymethylcellulose calcium (1.5 g) (as)
[英文别名 ]:
- Carboxymethyloxysuccinate
- 2-Oxa-1,3,4-butantricarbonsaeure
- 2-(carboxymethyloxy)butanedioic acid
- carboxymethyl ether,calcium salt
- CARBOXYMETHYLOXYSUCCINIC ACID
- (Carboxymethoxy) succinic acid
- carboxymethyl cellulose-calcium
羧甲基纤维素钙生物活性
[ 描述 ]:
羧甲基纤维素钙可用作赋形剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。
[ 相关类别 ]:
[参考文献]
羧甲基纤维素钙物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
557.1±50.0 °C at 760 mmHg
[ 分子式 ]:
C23H30ClN3O
[ 分子量 ]:
399.957
[ 闪点 ]:
290.7±30.1 °C
[ 精确质量 ]:
399.207733
[ PSA ]:
40.62000
[ LogP ]:
5.22
[ 外观性状 ]:
白色至淡黄色固体
[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C
[ 折射率 ]:
1.623
[ 储存条件 ]:
室温，密封
羧甲基纤维素钙毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FJ5850000
- CHEMICAL NAME :
- Cellulose, carboxymethyl ether, calcium salt
- CAS REGISTRY NUMBER :
- 9050-04-8
- LAST UPDATED :
- 199701
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Kidney, Ureter, Bladder - changes in bladder weight
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >300 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6800 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Kidney, Ureter, Bladder - changes in bladder weight
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >300 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >300 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52 mg/m3/17W-I
- TOXIC EFFECTS :
- Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 52 mg/m3/17W-I
- TOXIC EFFECTS :
- Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2450 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 738 (estimated) No. of Female Employees: 369 (estimated)
点击显示
羧甲基纤维素钙安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H317-H334
[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311
[ 危险品运输编码 ]:
NONH for all modes of transport
[ 海关编码 ]:
3912310000
羧甲基纤维素钙制备
羧甲基纤维素钠的水溶液内添加氢氧化钙，使其沉淀而得。
点击显示
羧甲基纤维素钙海关
[ 海关编码 ]: 3912310000
相关化工产品/化学物质：
推荐生产厂家/供应商：
相关化合物
【羧甲基纤维素钙】化源网提供羧甲基纤维素钙CAS号9050-04-8，羧甲基纤维素钙MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询羧甲基纤维素钙上化源网，专业又轻松。>>电脑版：羧甲基纤维素钙
标题：羧甲基纤维素钙_用途_密度_沸点_CAS号【9050-04-8】_化源网 地址：https://m.chemsrc.com/mip/cas/9050-04-8_1042312.html