GSK-3 BETA

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
746.6±60.0 °C at 760 mmHg

[ 分子式 ]:
C₃₄H₄₂N₄

[ 分子量 ]:
506.724

[ 闪点 ]:
405.3±32.9 °C

[ 精确质量 ]:
506.340942

[ LogP ]:
10.75

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.664

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors.

ACS Chem. Neurosci. 6 , 911-9, (2015)

Many current therapies target G protein coupled receptors (GPCR), transporters, or ion channels. In addition to directly targeting these proteins, disrupting the protein-protein interactions that loca...

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.

Nature 406(6791) , 86-90, (2000)

Glycogen synthase kinase-3 (GSK-3)-alpha and -beta are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation ...

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.

Genes Dev. 12(22) , 3499-511, (1998)

The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle engine that regulates DNA replication and mitosis. Induction of D-type cycli...

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