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奥索地平

奥索地平名称

[ CAS 号 ]:
90729-41-2

[ 中文名 ]:
奥索地平

[ 英文名 ]:
Oxodipine

[英文别名 ]:

奥索地平物理化学性质

[ 密度 ]:
1.247g/cm3

[ 沸点 ]:
470ºC at 760 mmHg

[ 分子式 ]:
C19H21NO6

[ 分子量 ]:
359.37300

[ 闪点 ]:
238ºC

[ 精确质量 ]:
359.13700

[ PSA ]:
83.09000

[ LogP ]:
2.71500

[ 折射率 ]:
1.552

奥索地平毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7968500
CHEMICAL NAME :
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-, ethyl methyl ester
CAS REGISTRY NUMBER :
90729-41-2
LAST UPDATED :
199406
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H21-N-O6
MOLECULAR WEIGHT :
359.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,633,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 54(2),40,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2160 mg/kg/13W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Endocrine - other changes Endocrine - changes in adrenal weight
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 20,549,1992
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区域:上海市普陀区

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联系人:徐经理

产品详情:奥索地平


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