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7-氟苯呋咱-4-硫氨

7-氟苯呋咱-4-硫氨用途

4-(氨基磺酰基)-7-氟-2,1,3-苯并恶二唑(ABD-F)是一种灵敏、特异检测硫醇的荧光试剂。4-(氨基磺酰基)-7-氟-2,1,3-苯并恶二唑具有低荧光背景和良好的荧光团稳定性[1]。

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7-氟苯呋咱-4-硫氨名称

[ CAS 号 ]:
91366-65-3

[ 中文名 ]:
7-氟苯呋咱-4-硫氨

[ 英文名 ]:
ABD-F

[中文别名 ]:

[英文别名 ]:

7-Fluoro-2,1,3-benzoxadiazole-4-sulfonamide
2,1,3-Benzoxadiazole-4-sulfonamide, 7-fluoro-
MFCD00036687

7-氟苯呋咱-4-硫氨生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Toyooka T, et al. New fluorogenic reagent having halogenobenzofurazan structure for thiols: 4-(aminosulfonyl)-7-fluoro-2, 1, 3-benzoxadiazole. Analytical chemistry, 1984, 56(13): 2461-2464.

7-氟苯呋咱-4-硫氨物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
408.8±55.0 °C at 760 mmHg

[ 熔点 ]:
145-146ºC

[ 分子式 ]:
C₆H₄FN₃O₃S

[ 分子量 ]:
217.178

[ 闪点 ]:
201.0±31.5 °C

[ 精确质量 ]:
216.995743

[ PSA ]:
107.46000

[ LogP ]:
0.11

[ 外观性状 ]:
淡黄色固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.632

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Light Sensitive

[ 水溶解性 ]:
DMSO: soluble

7-氟苯呋咱-4-硫氨MSDS

7-氟苯呋咱-4-硫氨安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2935009090

7-氟苯呋咱-4-硫氨合成路线

7-氟苯呋咱-4-硫氨上下游产品

7-氟苯呋咱-4-硫氨上游产品

7-氟苯呋咱-4-硫氨下游产品

7-氟苯呋咱-4-硫氨海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

7-氟苯呋咱-4-硫氨文献

Quantification of glutathione in plasma samples by HPLC using 4-fluoro-7-nitrobenzofurazan as a fluorescent labeling reagent.

J. Chromatogr. Sci. 50 , 119-122, (2012)

A rapid and highly sensitive high-performance liquid chromatograpy method with fluorescence detection has been developed for determination of glutathione (GSH) in human plasma. A simple pre-column der...

Plasma thiols levels in Alzheimer's disease mice under diet-induced hyperhomocysteinemia: effect of S-adenosylmethionine and superoxide-dismutase supplementation.

J. Alzheimers Dis. 44(4) , 1323-31, (2015)

Widely confirmed reports were published on association between hyperhomocysteinemia, B vitamin deficiency, oxidative stress, and amyloid-β in Alzheimer's disease (AD). Homocysteine, cysteine, cysteiny...

Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue.

Biochemistry 44(21) , 7704-12, (2005)

The fluorogenic reagent 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABDF) attenuates the functional activity of the protein tyrosine phosphatase PTP1B by reacting selectively with a single cystei...

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