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甲烯土霉素

甲烯土霉素名称

[ CAS 号 ]:
914-00-1

[ 中文名 ]:
甲烯土霉素

[ 英文名 ]:
methacycline

[中文别名 ]:

美他环素

[英文别名 ]:

Germicilclin
Adriamicina
gs-2876
6-methylene-oxytetracyclin
METHACYCLINE
Globociclina
6-methyleneoxytetracycline
rondomycin
metacycline
bialatan

甲烯土霉素物理化学性质

[ 密度 ]:
1.66g/cm3

[ 沸点 ]:
695.1ºC at 760mmHg

[ 熔点 ]:
>150°C (dec.) (lit.)

[ 分子式 ]:
C₂₂H₂₂N₂O₈

[ 分子量 ]:
442.41900

[ 闪点 ]:
374.2ºC

[ 精确质量 ]:
442.13800

[ PSA ]:
181.62000

[ LogP ]:
0.26240

[ 外观性状 ]:
黄色至棕色固体

[ 折射率 ]:
1.753

[ 储存条件 ]:
2-8°C

甲烯土霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9275000

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-

CAS REGISTRY NUMBER :: 914-00-1

LAST UPDATED :: 199506

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H22-N2-O8

MOLECULAR WEIGHT :: 442.46

WISWESSER LINE NOTATION :: L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 3750 ug/L

REFERENCE :: BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year: 16,127,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1538 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated)

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