< 生产厂家价格 >

2-氯吩噻嗪

2-氯吩噻嗪用途

【用途一】
用作药物盐酸氯丙嗪的中间体
【用途二】
医药中间体，用于制备氯丙嗪、奋乃静。

点击显示

2-氯吩噻嗪名称

[ CAS 号 ]:
92-39-7

[ 中文名 ]:
2-氯吩噻嗪

[ 英文名 ]:
2-Chlorophenothiazine

[中文别名 ]:

[英文别名 ]:

EINECS 202-152-5
10H-Phenothiazine, 2-chloro-
2-Chloro-10H-phenothiazine
MFCD00005016

2-氯吩噻嗪物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
395.7±31.0 °C at 760 mmHg

[ 熔点 ]:
195-200 °C(lit.)

[ 分子式 ]:
C₁₂H₈ClNS

[ 分子量 ]:
233.717

[ 闪点 ]:
193.1±24.8 °C

[ 精确质量 ]:
233.006592

[ PSA ]:
37.33000

[ LogP ]:
5.18

[ 外观性状 ]:
灰色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.680

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 水溶解性 ]:
水溶性：微溶；可溶于：乙醇,丙酮,苯,乙醚

2-氯吩噻嗪MSDS

2-氯吩噻嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN7580000

CHEMICAL NAME :: Phenothiazine, 2-chloro-

CAS REGISTRY NUMBER :: 92-39-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H8-Cl-N-S

MOLECULAR WEIGHT :: 233.72

WISWESSER LINE NOTATION :: T C666 BM ISJ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 160 mg/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1205,1977

点击显示

2-氯吩噻嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SN7580000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2934300000

2-氯吩噻嗪合成路线

2-氯吩噻嗪上下游产品

2-氯吩噻嗪上游产品

2-氯吩噻嗪下游产品

2-氯吩噻嗪制备

由间氯二苯胺经环合而得。在反应锅内加入间氯二苯胺和硫磺，升温至70℃，加入碘。升温至120℃，减压排出硫化氢，再升温至168-172℃，保温0.5h。冷却，加入氯苯和活性炭，加热回流1h。趁热过滤，滤液冷至15℃结晶。甩滤，用氯苯、乙醇洗涤滤饼各1次，得2-氯吩噻嗪。

点击显示

2-氯吩噻嗪海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氯吩噻嗪文献

Reversing the Warburg effect as a treatment for glioblastoma.

J. Biol. Chem. 288(13) , 9153-64, (2013)

Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the War...

Broad specific enzyme-linked immunosorbent assay for determination of residual phenothiazine drugs in swine tissues.

Anal. Biochem. 454 , 7-13, (2014)

In this study, a novel generic hapten of phenothiazine drugs was synthesized by derivatization of 2-chlorophenothiazine with sodium bromoacetate. Then the hapten was coupled to bovine serum albumin fo...

N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

J. Med. Chem. 54 , 4247-63, (2011)

A total of 53 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues, were synthesized and evaluated for antiproliferative activity, interaction with tubulin, and cell cyc...

更多文献

2-氯吩噻嗪

2-氯吩噻嗪用途

2-氯吩噻嗪名称

2-氯吩噻嗪物理化学性质

2-氯吩噻嗪MSDS

详细MSDS(安全技术说明书)

2-氯吩噻嗪毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2-氯吩噻嗪安全信息

2-氯吩噻嗪合成路线

详细合成路线

2-氯吩噻嗪上下游产品

2-氯吩噻嗪上游产品

2-氯吩噻嗪下游产品

2-氯吩噻嗪制备

2-氯吩噻嗪海关

2-氯吩噻嗪文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物