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2-(4-氯-2-甲基苯氧基)丙酸

2-(4-氯-2-甲基苯氧基)丙酸用途

美托洛普是一种除草剂[1]。

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2-(4-氯-2-甲基苯氧基)丙酸名称

[ CAS 号 ]:
93-65-2

[ 中文名 ]:
2-(4-氯-2-甲基苯氧基)丙酸

[ 英文名 ]:
Mecoprop

[中文别名 ]:

[英文别名 ]:

2-MCPP
EINECS 202-264-4
Propanoic acid,2-(4-chloro-2-methylphenoxy)-
2-(4-Chloro-2-methylphenoxy)propanoic acid
MFCD00002648
UNII:74N8TKR9P8
COMPITOX
U 46
2M-4CP
Clonotox

2-(4-氯-2-甲基苯氧基)丙酸生物活性

[ 描述 ]:

美托洛普是一种除草剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

美托洛普(6.25和 62.5微米)可提高卵母细胞孵育培养基中睾酮 (62.5微米)和雌二醇 (6.25μM)浓度[1]

[参考文献]

[1]. Orton F, et al. Endocrine disrupting effects of herbicides and pentachlorophenol: in vitro and in vivo evidence. Environ Sci Technol. 2009 Mar 15;43(6):2144-50.

2-(4-氯-2-甲基苯氧基)丙酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
331.9±27.0 °C at 760 mmHg

[ 熔点 ]:
88-90ºC

[ 分子式 ]:
C₁₀H₁₁ClO₃

[ 分子量 ]:
214.65

[ 闪点 ]:
154.5±23.7 °C

[ 精确质量 ]:
214.039673

[ PSA ]:
46.53000

[ LogP ]:
2.84

[ 外观性状 ]:
无色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.542

[ 储存条件 ]:
APPROX 4°C

[ 水溶解性 ]:
水溶性：不溶；水溶解度：880 mg/l 25 °C；易溶于：二乙醚,丙酮,乙醇；可溶于：氯仿

2-(4-氯-2-甲基苯氧基)丙酸MSDS

2-(4-氯-2-甲基苯氧基)丙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE9750000

CHEMICAL NAME :: Propionic acid, 2-((4-chloro-o-tolyl)oxy)-

CAS REGISTRY NUMBER :: 93-65-2

BEILSTEIN REFERENCE NO. :: 2212752

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C10-H11-Cl-O3

MOLECULAR WEIGHT :: 214.66

WISWESSER LINE NOTATION :: QVY1&OR DG B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 402 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 369 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14400 mg/kg/90D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 15 gm/kg/3W-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 55,197,1978 *** REVIEWS *** IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,357,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,156,1987 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4007 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 104 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4007 No. of Facilities: 263 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1578 (estimated)

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2-(4-氯-2-甲基苯氧基)丙酸安全信息

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R22;R38;R41;

[ 安全声明 (欧洲) ]:
S26;S37/S39

[ 危险类别 ]:
3.2

[ 海关编码 ]:
2918990022

2-(4-氯-2-甲基苯氧基)丙酸合成路线

2-(4-氯-2-甲基苯氧基)丙酸上下游产品

2-(4-氯-2-甲基苯氧基)丙酸上游产品

2-(4-氯-2-甲基苯氧基)丙酸下游产品

2-(4-氯-2-甲基苯氧基)丙酸海关

[ 海关编码 ]: 2918990022

[ 中文概述 ]:
2918990022. 2甲4氯、2甲4氯丙酸等〔包括精2甲4氯丙酸〕. 增值税率:17.0%. 退税率:9.0%. 监管条件:S(进出口农药登记证明). 最低关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2918990022 2-(4-chloro-2-methylphenoxy)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%