2-苯基吲哚

2-苯基吲哚用途

【用途一】
用作PVC玻璃纸稳定剂及染料中间体
【用途二】
该品主要作为阳离子染料中间体，用于生产阳离子橙2GL、阳离子红BL、阳离子红2GL，用于染料生产时往往先经甲基化，进一步制成N-甲基-2-苯基吲哚。甲基化剂为硫酸二甲酯，反应在氯苯溶剂中进行，在60-65℃反应，收率为83.5%。2-苯基吲哚也用作乳液法聚氯乙烯的热稳定剂。

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2-苯基吲哚名称

[ CAS 号 ]:
948-65-2

[ 中文名 ]:
2-苯基吲哚

[ 英文名 ]:
2-Phenylindole

[中文别名 ]:

[英文别名 ]:

1H-Indole, 2-phenyl-
EINECS 213-436-3
MFCD00005608
2-Phenyl-1H-indole
A-PHENYLINDOL
2-phenyl-indol
a-Phenylindole
Indole,2-phenyl
2-pPhenyl-1H-indole
2-phenyl-1h-indol

2-苯基吲哚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
419.9±0.0 °C at 760 mmHg

[ 熔点 ]:
188-190 °C(lit.)

[ 分子式 ]:
C₁₄H₁₁N

[ 分子量 ]:
193.244

[ 闪点 ]:
176.6±11.9 °C

[ 精确质量 ]:
193.089142

[ PSA ]:
15.79000

[ LogP ]:
4.68

[ 外观性状 ]:
灰白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
室温

2-苯基吲哚MSDS

2-苯基吲哚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1272500

CHEMICAL NAME :: Indole, 2-phenyl-

CAS REGISTRY NUMBER :: 948-65-2

BEILSTEIN REFERENCE NO. :: 0132356

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H11-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,44,1960

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2-苯基吲哚安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335-H413

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R37/38;R41

[ 安全声明 (欧洲) ]:
S26-S39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NM1272500

[ 海关编码 ]:
2933990090

2-苯基吲哚合成路线

2-苯基吲哚上下游产品

2-苯基吲哚上游产品

2-苯基吲哚下游产品

2-苯基吲哚制备

由苯肼与苯乙酮缩合后，再在氯化锌存在下闭环而制得2-苯基吲哚。除上述的Fisher法外，可将溴代苯乙酮与过量的苯胺加热反应，或将N-（2-甲基苯基）苯甲酰胺和乙醇钠隔绝空气于360-380℃加热，都可制得2-苯基吲哚。原料消耗定额：苯乙酮（98%）735kg/t、苯肼（游离100%）675kg/t、二甲苯900kg/t、冰醋酸15kg/t、氯化锌1230kg/t、盐酸（30%）810kg/t。

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2-苯基吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-苯基吲哚文献

Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.

J. Pineal Res. 58(3) , 310-20, (2015)

Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In...

The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.

PLoS Genet. 10(9) , e1004659, (2014)

The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and ...

Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.

PLoS ONE 10(2) , e0118188, (2015)

Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. T...

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2-苯基吲哚

2-苯基吲哚用途

2-苯基吲哚名称

2-苯基吲哚物理化学性质

2-苯基吲哚MSDS

详细MSDS(安全技术说明书)

2-苯基吲哚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2-苯基吲哚安全信息

2-苯基吲哚合成路线

详细合成路线

2-苯基吲哚上下游产品

2-苯基吲哚上游产品

2-苯基吲哚下游产品

2-苯基吲哚制备

2-苯基吲哚海关

2-苯基吲哚文献

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