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肿瘤坏死因子-α 人

肿瘤坏死因子-α 人用途

肿瘤坏死因子-α （TNF-α）是强效促炎细胞因子，在类风湿关节炎病变、银屑病关节炎（PsA）和银屑病中起作用。刺激白介素IL-1和IL-6。TNF-α 基因的多态性与PsA的破坏性关节病有关。TNF-α的翻译后修饰对其功能至关重要。

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肿瘤坏死因子-α 人名称

[ CAS 号 ]:
94948-59-1

[ 中文名 ]:
人重组肿瘤坏死因子

[ 英文名 ]:
Tumor Necrosis Factor-α, human

[英文别名 ]:

MFCD00148692

肿瘤坏死因子-α 人物理化学性质

[ 分子式 ]:
C₂₈H₂₁Cl₃N₆O₉

[ 分子量 ]:
691.86000

[ 精确质量 ]:
690.04400

[ PSA ]:
201.89000

[ LogP ]:
8.79460

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

肿瘤坏死因子-α 人MSDS

详细MSDS(安全技术说明书)

肿瘤坏死因子-α 人毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MT6435000

CHEMICAL NAME :: Human recombinant tumor necrosis factor-alpha

CAS REGISTRY NUMBER :: 94948-59-1

LAST UPDATED :: 199610

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 ug/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 1 ku/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 ku/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1355,1991

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肿瘤坏死因子-α 人安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MT6435000

肿瘤坏死因子-α 人文献

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Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.

Sci. Signal. 8 , ra86, (2015)

Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate inna...

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

Cell Death Dis. 6 , e1767, (2015)

Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3. Necroptotic cell death contributes to the pathophysiology o...

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