乙基雌烯醇
乙基雌烯醇用途
用作医药中间体
乙基雌烯醇名称
[ CAS 号 ]:
965-90-2
[ 中文名 ]:
乙基雌烯醇
[ 英文名 ]:
Ethylestrenol
[中文别名 ]:
[英文别名 ]:
- orgabolin
- Orgaboral
- ETHYLESTRENOL
- durabolin-o
- maxibolin
- duraboral
- org-483
- MFCD00198958
- EINECS 213-523-6
- maxibalin
乙基雌烯醇物理化学性质
[ 密度 ]:
1.04 g/cm3
[ 沸点 ]:
401.4ºC at 760 mmHg
[ 熔点 ]:
76-78ºC
[ 分子式 ]:
C20H32O
[ 分子量 ]:
288.46700
[ 闪点 ]:
167.4ºC
[ 精确质量 ]:
288.24500
[ PSA ]:
20.23000
[ LogP ]:
5.09030
[ 折射率 ]:
1.547
乙基雌烯醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC8961100
- CHEMICAL NAME :
- 19-Nor-17-alpha-pregn-4-en-17-ol
- CAS REGISTRY NUMBER :
- 965-90-2
- LAST UPDATED :
- 199103
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C20-H32-O
- MOLECULAR WEIGHT :
- 288.52
- WISWESSER LINE NOTATION :
- L E5 B666 MUTJ E1 FQ F2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >666700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,113,1982 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 2-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 22,735,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 15-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 22,735,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 17-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- male 15 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,768,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 28 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,489,1972
乙基雌烯醇安全信息
[ 危险品运输编码 ]:
UN 3249
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
乙基雌烯醇合成路线
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