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对-α-二溴苯乙酮

对-α-二溴苯乙酮用途

【用途一】
分析试剂。该品为有机有毒品。
【用途二】
分析试剂。用于HPLC标记。

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对-α-二溴苯乙酮名称

[ CAS 号 ]:
99-73-0

[ 中文名 ]:
2,4'-二溴苯乙酮

[ 英文名 ]:
2,4′-dibromoacetophenone

[中文别名 ]:

[英文别名 ]:

2-Bromo-1-(4-bromophenyl)ethanone
BromophenacylBromide
PBPB
2,4'-Dibromoacetophenone
p-Bromophenacyl bromide
2-bromo-1-(4-bromophenyl)-1-ethanone
Ethanone, 2-bromo-1- (4-bromophenyl)-
2-bromo-4'-bromoacetophenone
2,4`-Dibromoacetophenone
2,4'-Dibromo-acetophenone

对-α-二溴苯乙酮物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
310.4±22.0 °C at 760 mmHg

[ 熔点 ]:
108-110 °C(lit.)

[ 分子式 ]:
C₈H₆Br₂O

[ 分子量 ]:
277.941

[ 闪点 ]:
114.1±8.9 °C

[ 精确质量 ]:
275.878540

[ PSA ]:
17.07000

[ LogP ]:
2.95

[ 外观性状 ]:
灰白色晶体或粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.604

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.

对-α-二溴苯乙酮MSDS

对-α-二溴苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM6950000

CHEMICAL NAME :: Acetophenone, 2,4'-dibromo-

CAS REGISTRY NUMBER :: 99-73-0

BEILSTEIN REFERENCE NO. :: 0607604

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H6-Br2-O

MOLECULAR WEIGHT :: 277.96

WISWESSER LINE NOTATION :: E1VR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02407 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5162 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

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对-α-二溴苯乙酮安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3261 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
AM6950000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29147090

对-α-二溴苯乙酮合成路线

对-α-二溴苯乙酮上下游产品

对-α-二溴苯乙酮上游产品

对-α-二溴苯乙酮下游产品

对-α-二溴苯乙酮制备

1.由对溴苯乙酮溴化而得。将对溴苯乙酮溶解在冰醋酸中，在20℃以下滴加溴素。

2.在装有搅拌器、分液漏斗和回流冷凝器〔与氯化氢吸收槽 (图5)连接〕的5升三颈烧瓶中，放置392克(2.5摩尔)嗅苯溶于1升干燥二硫化碳的溶液(防火!注1)，加750克(5.6摩尔)无水三氯化铝。在蒸气浴上加热至缓缓回流，然后滴加204克(2摩尔)乙醉(bp 136一139℃)，历时l时。在滴加过程中及滴完后的1小时内，都应保持缓缓的回流状态。反应进行时伴随大量氧化氢逸出，即使加热之后，也并不完全停止。在蒸气浴上直接从烧瓶甲蒸出二硫化嵌。稍冷而残余物又尚温热时，边搅拌边慢慢地将其倾入混和有盐酸的碎冰中瓶中残留的少量三氯化铝加成产物用冰一盐酸分解后，合并子上面的冰水溶液中，此时总体积约为5升。每2升混和液用300毫升和200毫升苯(或乙醚)各萃取2次。合并萃取液，水洗两次。10%氢氧化钠溶液洗涤后再用水洗2次，直至水洗涤液几乎无色，并能使两相溶液快速分层以及所有沉淀都随水洗液一起分离出来为止。苯溶液中加30克无水氯化钙干燥1小时，过滤，在蒸气浴上蒸出溶剂。残余物在短松针分馏柱上减压蒸馏。在低沸点物质首先被蒸出后，温度迅速上升。如果在水解一步处理细，且所有铝盐都被除去，产物应该是水自色的馏分(沸程3℃)，冷却则成白色结晶。

3.在一个500毫升烧瓶中放置50克(0.25摩尔)对溴苯乙酮和100毫升冰乙酸，维持温度在20℃以下，边搅拌边慢慢滴加40克( 12.5毫升，0.25摩尔)溴。当滴入半量的澳以后，ω一溴对溴苯乙酮的针状晶体开始析出。全部嗅加完(历时30分钟)后杯置于冰浴中冷却。吸滤，粗产物用100毫升50%的乙醇洗涤至无色，晾千后重55一60克。在400毫升95%乙醇中重结晶，得40一50克(69-72%)无色针状晶体。

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对-α-二溴苯乙酮海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

对-α-二溴苯乙酮文献

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

J. Med. Chem. 54 , 4042-56, (2011)

Development of kinase-targeted therapies for central nervous system (CNS) diseases is a great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe CNS unmet diseases, bein...

Identification and characterisation of novel inhibitors on extrinsic tenase complex from Bungarus fasciatus (banded krait) venom.

Thromb. Haemost. 112(4) , 700-15, (2014)

Snake venoms are excellent sources of pharmacologically active proteins and peptides, and hence are potential sources of leads for drug developments. It has been previously established that krait (Bun...

Effects of vipoxin and its components on HepG2 cells.

Toxicon 94 , 36-44, (2015)

Snake venom Phospholipases A2 (svPLA2) are among the main toxic venom components with a great impact on different tissues and organs based on their catalytic specificity and a variety of pharmacologic...

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对-α-二溴苯乙酮

对-α-二溴苯乙酮用途

对-α-二溴苯乙酮名称

对-α-二溴苯乙酮物理化学性质

对-α-二溴苯乙酮MSDS

详细MSDS(安全技术说明书)

对-α-二溴苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

对-α-二溴苯乙酮安全信息

对-α-二溴苯乙酮合成路线

详细合成路线

对-α-二溴苯乙酮上下游产品

对-α-二溴苯乙酮上游产品

对-α-二溴苯乙酮下游产品

对-α-二溴苯乙酮制备

对-α-二溴苯乙酮海关

对-α-二溴苯乙酮文献

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