米勃龙
米勃龙名称
[ CAS 号 ]:
3704-09-4
[ 中文名 ]:
米勃龙
[ 英文名 ]:
Mibolerone
[中文别名 ]:
[英文别名 ]:
- MIBOLERONE
- U-10,997
- Miboleron
- CDB 904
- Miboleronum
- [3H]-Mibolerone
- MFCD00221774
- Cheque
- Mibolerona
- EINECS 223-046-5
米勃龙物理化学性质
[ 密度 ]:
1.1g/cm3
[ 沸点 ]:
440.5ºC at 760mmHg
[ 熔点 ]:
168-171ºC
[ 分子式 ]:
C20H30O2
[ 分子量 ]:
302.45100
[ 闪点 ]:
187.8ºC
[ 精确质量 ]:
302.22500
[ PSA ]:
37.30000
[ LogP ]:
4.12520
[ 外观性状 ]:
白色结晶固体
[ 折射率 ]:
1.553
[ 储存条件 ]:
Controlled Substance, -20?C Freezer
米勃龙毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG7980000
- CHEMICAL NAME :
- Estr-4-en-3-one, 17-beta-hydroxy-7-alpha,17-dimethyl-
- CAS REGISTRY NUMBER :
- 3704-09-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C20-H30-O2
- MOLECULAR WEIGHT :
- 302.50
- WISWESSER LINE NOTATION :
- L E5 B666 OVTJ E1 FQ F1 K1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8985 ug/kg/9.6Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 13,177,1985 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 800 ug/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 9,235,1967
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 196 ug/kg
- SEX/DURATION :
- female 6-61 day(s) after conception lactating female 42 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940- Volume(issue)/page/year: 39,837,1978
米勃龙安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H360
[ 警示性声明 ]:
P201-P308 + P313
[ 危害码 (欧洲) ]:
T
[ 风险声明 (欧洲) ]:
60-63
[ 安全声明 (欧洲) ]:
36-45
[ 危险品运输编码 ]:
NONH for all modes of transport
米勃龙文献
J. Steroid Biochem. Mol. Biol. 111(3-5) , 275-81, (2008)
In this study, we report the synthesis and biological evaluation of several new 3-substituted pregna-4,16-diene-6,20-dione derivatives (11a-11d). These compounds were prepared from the commercially av...
Steroid and beta-adrenergic receptor modifications in target organs of broiler chickens fed with a diet containing beta2-adrenergic agents.Food Chem. Toxicol. 46(6) , 2239-43, (2008)
The illegal use of beta2-agonists as repartitioning agents to improve production performance and carcass composition can induce changes in various organs of exposed animals. The aim of the present stu...
Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5alpha-reductase.J. Steroid Biochem. Mol. Biol. 107(1-2) , 48-56, (2007)
In order to study the biological activity of the two novel steroidal carbamates derivatives: 8a and 8b, we determined the concentration of both compounds that inhibit the 50% of the activity of human ...
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