水飞蓟宾

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更新时间： 2025-10-23 15:08:21

CAS号：22888-70-6

常用名： 水飞蓟宾A

价格：
￥80.0/20mg

纯度： 98.0%

备货期： 1天

库存： 900 mg

其他详情（用途，包装）：
用途： Silibinin, an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.IC50 value:Target: anticancerin vitro: silibinin significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines, suggesting that silibinin-induced NAG-1 up-regulation is p53-independent manner.Silibinin up-regulates early growth response-1 (EGR-1) expression [1]. silibinin induced cell death in human breast cancer cell lines MCF7 and MDA-MB-231. Silibinininduced cell death was attenuated by antioxidants, N-acetylcysteine (NAC) and Trolox, suggesting that the effect of silibinin was dependent on generation of reactive oxygen species (ROS) [2]. SIL treatment resulted in a dose- and time-dependent inhibition of HCC cell viability, SIL exhibited strong antitumor activity, as evidenced not only by reductions in tumor cell adhesion, migration, intracellular glutathione (GSH) levels and total antioxidant capability (T-AOC) but also by increases in the apoptotic index, caspase3 activity, and reactive oxygen species (ROS). SIL treatment decreased the expression of the Notch1 intracellular domain (NICD), RBP-Jκ, and Hes1 proteins, upregulated the apoptosis pathway-related protein Bax, and downregulated Bcl2, survivin, and cyclin D1. Notch1 siRNA (in vitro) or DAPT (a known Notch1 inhibitor, in vivo) further enhanced the antitumor activity of SIL, and recombinant Jagged1 protein (a known Notch ligand in vitro) attenuated the antitumor activity of SIL [3].in vivo: Topical application of silibinin at the dose of 9 mg/mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis[4]. The kidney cortex of vehicle-treated control OVE26 mice displayed greater Nox4 expression and twice as much superoxide production than cortex of silybin-treated mice. The glomeruli of control OVE26 mice displayed 35% podocyte drop out that was not present in the silybin-treated mice [5]. 物理化学性质： CAS号：22888-70-6 常用中文名：水飞蓟宾A 常用英文名：Silymarin 分子式：C25H22O10 分子量：482.436 密度：1.5±0.1 g/cm3 沸点：793.0±60.0 °C at 760 mmHg 熔点：164-174°C 闪点：274.5±26.4 °C 储存条件：−20°C

供应商信息：

公司名：上海源叶生物科技有限公司

认证状态： 未认证供应商

商品数： 5711件

电话： 61559134

地址： 上海市松江区长塔路465号6幢

地区： 上海市松江区

联系人： 何喜莲

联系人电话： 15921386130 021-61559134

邮件：3285254746@qq.com

网址：http://www.shyuanye.com

主要市场：国内

年贸易额：￥1000万-5000万

外贸占销售比例：

主要合作伙伴：

公司介绍：
上海源叶生物科技有限公司是一家专门从事生物技术相关产品研发和销售的综合性生命科学公司，在全体员工的不懈努力和广大客户的大力支持下，公司迅速成长为一家拥有生物试剂部、实验部、生命科学仪器部以及技术服务部等部门的高新技术企业。公司地址：上海市杨浦区黄兴路1999号2号楼8E 我们的理念: 客户至上、服务至真；质量第一、诚信为本

其他供应商价格：

2024-09-29 价格：￥需询单水飞蓟宾

2022-02-19 价格：￥122.9 Silibinin

2019-03-05 价格：￥918.0 水飞蓟宾

2025-12-29 价格：￥需询单水飞蓟宾A

2024-07-15 价格：需询单水飞蓟宾

2024-09-13 价格：￥需询单水飞蓟宾

2018-05-16 价格：￥需询单水飞蓟素

2018-07-12 价格：￥280.0 水飞蓟素

2020-12-08 价格：￥1582.0 西利马灵

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水飞蓟宾A价格

水飞蓟宾

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