芦荟大黄素

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更新时间： 2024-10-01 16:53:48

CAS号：481-72-1

常用名： 芦荟大黄素

价格：
￥1850.0/1kg

纯度： 98.0%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
用途： Aloe emodin is a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antitumor activity.IC50 value:Target:in vitro: aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ER α and increased ER α ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ER α degradation [1]. Aloe-emodin, a natural compound found in aloe, inhibited both proliferation and anchorage-independent growth of PC3 cells. Protein content analysis suggested that activation of the downstream substrates of mTORC2, Akt and PKCα, was inhibited by aloe-emodin treatment. Pull-down assay and in vitro kinase assay results indicated that aloe-emodin could bind with mTORC2 in cells and inhibit its kinase activity [2]. Of three anthraquinone derivatives, aloe-emodin, with a lower cytotoxicity showed concentration-dependently reducing virus-induced cytopathic effect and inhibiting replication of influenza A in MDCK cells. Galectin-3 also inhibited influenza A virus replication. Proteomic analysis of treated cells indicated galectin-3 up-regulation as one anti-influenza A virus action by aloe-emodin. Since galectin-3 exhibited cytokine-like regulatory actions via JAK/STAT pathways, aloe-emodin also restored NS1-inhibited STAT1-mediated antiviral responses in transfected cells: e.g., STAT1 phosphorylation of interferon (IFN) stimulation response element (ISRE)-driven promoter, RNA-dependent protein kinase (PKR) and 2'5',-oligoadenylate synthetase (2'5',-OAS) expression [3]. AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9, as well as the RhoB expression at gene and protein level. AE suppressed the nuclear translocation and DNA binding of NF-κB [4].in vivo: Aloe-emodin also exhibited tumor suppression effects in vivo in an athymic nude mouse model [2]. 物理化学性质： CAS号：481-72-1 常用中文名：芦荟大黄素常用英文名：Aloeemodin 分子式：C15H10O5 分子量：270.237 密度：1.6±0.1 g/cm3 沸点：568.8±50.0 °C at 760 mmHg 熔点：223-224°C 闪点：311.9±26.6 °C 储存条件：2-8°C

供应商信息：

公司名：杨凌慈缘生物技术有限公司

认证状态： 未认证供应商

商品数： 123件

电话： 029-81338601-8015

地址： 丰登南路2号

地区： 西安市莲湖区

联系人： 张涵

联系人电话： 15289457893

邮件：1415378652@qq.com

网址：http://www.ciybio.com

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2024-09-29 价格：￥需询单芦荟大黄素

2022-02-19 价格：￥310.9 芦荟大黄素

2024-07-15 价格：需询单芦荟大黄素

2025-12-29 价格：￥需询单芦荟大黄素

2019-03-05 价格：￥148.0 芦荟大黄素

2023-09-09 价格：￥1500.0 芦荟大黄素

2024-09-13 价格：￥需询单芦荟大黄素

2025-01-03 价格：￥需询单芦荟大黄素

2018-06-26 价格：￥1200.0 芦荟大黄素

2017-04-20 价格：￥150.0 芦荟大黄素

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