ELR-510444

产品详情：

更新时间： 2025-09-12 15:08:59

CAS号：1233948-35-0

常用名： ELR510444

价格：
￥需询单/25g ￥需询单/1g

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.IC50 value: 30.9 nM(MDA-MB-231 cell) [1]Target: Microtubule disruptorELR510444 is not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines, suggesting that it circumvents both clinically relevant mechanisms of drug resistance to this class of agents. ELR510444 also shows potent antitumor activity in the MDA-MB-231 xenograft model with at least a 2-fold therapeutic window. Studies in tumor endothelial cells show that a low concentration of ELR510444 (30 nM) rapidly alters endothelial cell shape, similar to the effect of the vascular disrupting agent combretastatin A4. ELR510444 is a novel microtubule-disrupting agent with potential antivascular effects and in vivo antitumor efficacy [1]. ELR510444 decreased HIF-1α and HIF-2α levels, reduced RCC cell viability and clonogenic survival, and induced apoptosis. VHL-deficient RCC cells were more sensitive to ELR510444-mediated apoptosis and restoration of VHL promoted drug resistance. Higher concentrations of ELR51044 promoted apoptosis independently of VHL status, possibly due to the microtubule destabilizing properties of this agent. ELR510444 significantly reduced tumor burden in the 786-O and A498 RCC xenograft models [2]. 物理化学性质： CAS号：1233948-35-0 常用中文名：ELR510444 常用英文名：ELR-510444 分子式：C19H16N2O2S2 分子量：368.473 密度：1.4±0.1 g/cm3 沸点：547.8±60.0 °C at 760 mmHg 熔点：N/A 闪点：285.1±32.9 °C 储存条件：-20℃

供应商信息：

公司名：上海禹犇生物科技有限公司

认证状态： 未认证供应商

商品数： 201件

电话： +8621-61350663

地址： 上海市奉贤区星火开发区莲塘路251号14幢20521室

地区： 上海市奉贤区

联系人： 丁先生

联系人电话： +86-15502154572

邮件：yuben012@sina.com

网址：https://www.chemsrc.com/saler/11152.html

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公司介绍：
上海禹犇生物科技有限公司是集医药化学品（含中间体）、精细化学品和生物医药产品的研究、开发、生产、产品销售、技术服务于一体的高新企业。

其他供应商价格：

2024-03-12 价格：￥799.9 ELR-510444

2024-07-15 价格：需询单 ELR510444

2021-02-06 价格：￥3839.0 ELR510444

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ELR510444价格

ELR-510444

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