Clevidipine

产品详情：

更新时间： 2024-09-20 09:51:00

CAS号：167221-71-8

常用名： 丁酸氯维地平

价格：
$需询单/1mg

纯度： 96.406%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.IC50 Value: 7.1 nM at V(H) = -40 mV [1]Target: calcium channelin vitro: Both clevidipine and nitroglycerin completely reversed U46619-induced contraction (clevidipine (50% effective concentration [EC50] = 3.88 +/- 0.84 x 10(-6) mol/L, nitroglycerin EC50 = 4.84 +/- 2.76 x 10(-8) mol/L) [2]. A decrease in temperature increased the half-life of clevidipine in blood, whereas dilution of the blood did not affect the in vitro half-life of clevidipine. The albumin concentration affected the hydrolysis rate of clevidipine in RBC suspended with saline [3].in vivo: Clevidipine is a high-clearance drug with a relatively small volume of distribution, resulting in an extremely short half-life in all species studied. The median initial half-life of the individual value (Bayesian estimates) is 12, 20, and 22 s in the rabbit, rat, and dog, respectively [4]. The extremely high clearance value and the small volume of distribution resulted in short half-lives of clevidipine, 2.2 and 16.8 min, respectively. The blood concentration and dose rate producing half the maximal effect (i.e. EC50 and ED50) were approximately 25 nM and 1.5 microg/kg/min, respectively [5].Clinical trial: CARVE: Clevidipine for Vasoreactivity Evaluation of the Pulmonary Arterial Bed. Phase 4 物理化学性质： CAS号：167221-71-8 常用中文名：丁酸氯维地平常用英文名：Clevidipine 分子式：C21H23Cl2NO6 分子量：456.316 密度：1.3±0.1 g/cm3 沸点：539.7±50.0 °C at 760 mmHg 熔点：128-130°C 闪点：280.2±30.1 °C 储存条件：Refrigerator

供应商信息：

公司名：Xin Yao (Shen zhen) Biotech Co., Ltd.

认证状态： 未认证供应商

商品数： 309件

电话： 0086 0755-89303680

地址： 3rd floor, No.27, Youyi Road, Wulian Community, Longcheng Street, Longgang District, Shenzhen,China

地区： China

联系人： Vivi Chen

联系人电话： 0086 15626500616

邮件：xinyaosz@xinyaosz.com

网址：https://en.xinyaosz.com/

主要市场：China, Europe, America, Asia

年贸易额：10 million USD

外贸占销售比例：

主要合作伙伴：TRC, HIC, EP, BP, Werfen Chromogenix,etc

公司介绍：

其他供应商价格：

2022-11-29 价格：￥需询单 Cleviprex

2025-09-17 价格：￥需询单丁酸氯维地平

2022-02-19 价格：￥147.9 氯维地平

2017-11-30 价格：￥需询单 4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸甲基(1-丁酰氧基)甲酯

2020-01-15 价格：￥需询单丁酸氯维地平

2017-08-06 价格：￥需询单丁酸氯维地平

2017-07-20 价格：￥需询单丁酸氯维地平

2025-04-09 价格：￥需询单丁酸氯维地平

2020-12-08 价格：￥1100.0 丁酸氯维地平

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丁酸氯维地平价格

Clevidipine

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