5'-Deoxy-5-fluorouridine

产品详情：

更新时间： 2023-04-05 00:48:56

CAS号：3094-09-5

常用名： 去氧氟尿苷

价格：
$需询单/1g

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Doxifluridine(Ro 21-9738; 5'-DFUR) is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM. IC50 value: 0.62 μM(PC9-DPE2 cell).Target: Nucleoside antimetabolite/analogDoxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.in vitro: 5'-DFUR's metabolic product(N3-Me-5'-dFUR) was found to be non-toxic in all the cell growth experiments performed. The absence of cytotoxicity could be explained by the observation that the metabolite was not recognized as a substrate by thymidine phosphorilase, the enzyme responsible for 5-fluorouracil (5-FU) release from doxifluridine, as ascertained by high-performance liquid chromatography/ultraviolet (HPLC-UV) analysis of the incubation mixture[1].in vivo: Administration of 200 mg of Furtulon to 23 beagle dogs, the plasma concentrations of doxifluridine, 5-FU, and 5-FUrd were measured simultaneously, using LC-MS/MS. The parent-metabolite compartment model with first-order absorption and Michaelis-Menten kinetics described the pharmacokinetics of doxifluridine, 5-FU, and 5-FUrd. Michaelis-Menten kinetics sufficiently explained the generation and elimination processes of 5-FU and 5-FUrd[2].Clinical trial: A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer was reported in 2009[3]. 物理化学性质： CAS号：3094-09-5 常用中文名：去氧氟尿苷常用英文名：Doxifluridine 分子式：C9H11FN2O5 分子量：246.192 密度：1.6±0.1 g/cm3 沸点：N/A 熔点：188-192 °C(lit.) 闪点：N/A 储存条件：-20°C Freezer

供应商信息：

公司名：Xin Yao (Shen zhen) Biotech Co., Ltd.

认证状态： 未认证供应商

商品数： 309件

电话： 0086 0755-89303680

地址： 3rd floor, No.27, Youyi Road, Wulian Community, Longcheng Street, Longgang District, Shenzhen,China

地区： China

联系人： Vivi Chen

联系人电话： 0086 15626500616

邮件：xinyaosz@xinyaosz.com

网址：https://en.xinyaosz.com/

主要市场：China, Europe, America, Asia

年贸易额：10 million USD

外贸占销售比例：

主要合作伙伴：TRC, HIC, EP, BP, Werfen Chromogenix,etc

公司介绍：

其他供应商价格：

2022-02-19 价格：￥43.9 5'-脱氧-5-氟尿苷

2019-03-05 价格：￥118.0 5'-脱氧-5-氟尿苷

2016-11-01 价格：￥350.0 去氧氟尿苷

2022-03-22 价格：￥需询单去氧氟尿苷/氟铁龙

2020-12-08 价格：￥509.0 去氧氟尿苷

2018-10-26 价格：￥需询单去氧氟尿苷 3094-09-5

2024-01-09 价格：$需询单 doxifluridine

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去氧氟尿苷价格

5'-Deoxy-5-fluorouridine

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