Alvimopan

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更新时间： 2025-09-18 13:16:09

CAS号：170098-38-1

常用名： 爱维莫潘

价格：
￥需询单/1g

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Alvimopan dihydrate(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. IC50 Value: 1.7 nM (Mu-type opioid receptor) [1]Target: mu-opioid receptorin vitro: The dissociation rate of alvimopan from the micro opioid receptor (t(1/2)=30--44 min) was comparable to that of the long acting partial agonist buprenorphine (t(1/2)=44 min), but was slower than those of the antagonists naloxone (t(1/2)=0.82 min) and N-methylnaltrexone (t(1/2)=0.46 min) [2].in vivo: Alvimopan did not significantly accelerate GI-3 compared with placebo [6 mg: hazard ratio (HR) = 1.20, p = 0.080; 12 mg: HR = 1.24, p = 0.038). However, after adjustment for significant covariates (sex/surgical duration), benefits were significant for both doses (6 mg: HR = 1.24, p = 0.037; 12 mg: HR = 1.26, p = 0.028). Alvimopan also significantly accelerated time to GI-2 (6 mg: HR = 1.37, p = 0.008; 12 mg: HR = 1.33, p = 0.018) and DCO (6 mg: HR = 1.31, p = 0.008; 12 mg: HR = 1.28, p = 0.015) [3]. Alvimopan (1 and 3 mg/kg) significantly reversed this delayed GI transit when administered 45 min prior to surgery. However, the effects of alvimopan were less pronounced when administered following surgery [4].Toxicity:The most common treatment-emergent adverse events across all treatment groups were nausea, vomiting, and hypotension; the incidence of nausea and vomiting was reduced by 53 percent in thealvimopan 12-mg group [5].Clinical trial: Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy. Phase 3 物理化学性质： CAS号：170098-38-1 常用中文名：爱维莫潘常用英文名：Alvimopan 分子式：C25H36N2O6 分子量：460.563 密度：1.166g/cm3 沸点：684.1ºC at 760mmHg 熔点：210-213ºC 闪点：367.5ºC 储存条件：-20℃

供应商信息：

公司名：杭州荣杉生物科技有限公司

认证状态： 未认证供应商

商品数： 123件

电话： +86-17788583750

地址： No.137 Fengqi Road, Jianggan Area, Hangzhou, Zhejiang Province

地区： 杭州市江干区

联系人： 岳洋

联系人电话： 17788583750

邮件：info@cyanochem.com

网址：http://www.cyanochem.com

主要市场：欧美、东南亚

年贸易额：500000000

外贸占销售比例：70%

主要合作伙伴：拜耳

公司介绍：
杭州荣杉生物科技有限公司是一家专业从事原料药及中间体研发、生产和销售的高科技医药化工产品企业。公司配备了先进的生产设备及检测设备，现已建立多个产品的稳定化生产线，能够满足客户从研发到生产的需求。公司生产的产品已远销欧美和东南亚等国家和地区，并与众多世界著名的制药、化工企业建立了互利互惠、共赢的合作伙伴关系。

其他供应商价格：

2022-03-04 价格：￥36952.9 爱维莫潘二水合物-d7

2022-01-13 价格：￥需询单爱维莫潘二水合物

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Alvimopan

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