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新乌头碱；中乌头碱

新乌头碱；中乌头碱用途

新乌头碱(Mesaconitine)是乌头属植物的主要活性成分,具有多种药学作用。

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新乌头碱；中乌头碱名称

[ CAS 号 ]:
2752-64-9

[ 中文名 ]:
中乌头碱

[ 英文名 ]:
Mesaconitine

[中文别名 ]:

[英文别名 ]:

Mesaaconitine
N-Desethyl-N-Methylaconitine
MESACONITINE(SH)
Japaconitine B
Japaconitine A
MESACONITINE (PRIMARY STANDARD)

新乌头碱；中乌头碱生物活性

[ 描述 ]:

新乌头碱(Mesaconitine)是乌头属植物的主要活性成分,具有多种药学作用。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> TNF受体

天然产物 >> 生物碱

研究领域 >> 其他

[参考文献]

[1]. Ogura J, et al. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004 Jan 12;483(2-3):139-46.

[2]. Mitamura M, et al. Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium. Eur J Pharmacol. 2002 Feb 2;436(3):217-25.

[3]. Murayama M, et al. Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. Eur J Pharmacol. 1984 May 18;101(1-2):29-36.

[相关活性小分子]

新乌头碱；中乌头碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
695.0±55.0 °C at 760 mmHg

[ 分子式 ]:
C₃₃H₄₅NO₁₁

[ 分子量 ]:
631.711

[ 闪点 ]:
374.1±31.5 °C

[ 精确质量 ]:
631.299255

[ PSA ]:
153.45000

[ LogP ]:
0.27

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

新乌头碱；中乌头碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5563000

CHEMICAL NAME :: Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1-alpha,3-alpha,6-alpha,14-alpha,15-alpha,16-beta)-

CAS REGISTRY NUMBER :: 2752-64-9

LAST UPDATED :: 199009

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C33-H45-N-O11

MOLECULAR WEIGHT :: 631.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 213 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,359,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 204 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 80 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 40 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981

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新乌头碱；中乌头碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H330

[ 警示性声明 ]:
P260-P264-P284-P301 + P310-P310

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

新乌头碱；中乌头碱合成路线

详细合成路线

新乌头碱；中乌头碱上下游产品

新乌头碱；中乌头碱上游产品

新乌头碱；中乌头碱下游产品

新乌头碱；中乌头碱文献

Vasorelaxing effect of mesaconitine, an alkaloid from Aconitum japonicum, on rat small gastric artery: possible involvement of endothelium-derived hyperpolarizing factor Mitamura M, et al

Jpn. J. Pharmacol. 89(4) , 380-7, (2002)

更多文献

新乌头碱；中乌头碱

新乌头碱；中乌头碱用途

新乌头碱；中乌头碱名称

新乌头碱；中乌头碱生物活性

新乌头碱；中乌头碱物理化学性质

新乌头碱；中乌头碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

新乌头碱；中乌头碱安全信息

新乌头碱；中乌头碱合成路线

详细合成路线

新乌头碱；中乌头碱上下游产品

新乌头碱；中乌头碱上游产品

新乌头碱；中乌头碱下游产品

新乌头碱；中乌头碱文献

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新乌头碱； 中乌头碱

新乌头碱； 中乌头碱用途

新乌头碱； 中乌头碱名称

新乌头碱； 中乌头碱生物活性

新乌头碱； 中乌头碱物理化学性质

新乌头碱； 中乌头碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

新乌头碱； 中乌头碱安全信息

新乌头碱； 中乌头碱合成路线

详细合成路线

新乌头碱； 中乌头碱上下游产品

新乌头碱； 中乌头碱上游产品

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新乌头碱；中乌头碱

新乌头碱；中乌头碱用途

新乌头碱；中乌头碱名称

新乌头碱；中乌头碱生物活性

新乌头碱；中乌头碱物理化学性质

新乌头碱；中乌头碱毒性和生态

新乌头碱；中乌头碱安全信息

新乌头碱；中乌头碱合成路线

新乌头碱；中乌头碱上下游产品

新乌头碱；中乌头碱上游产品

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新乌头碱；中乌头碱文献