乙胺嘧啶

产品详情：

更新时间： 2024-09-14 20:21:14

CAS号：58-14-0

常用名： 乙胺嘧啶

价格：
￥需询单/25kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).IC50 Value: 15.4 nM (Plasmodium falciparum) [1]Target: DHFR; antifolatein vitro: Three susceptibility levels (susceptible, intermediate, and resistant) were observed in the response of culture-adapted clones and strains to pyrimethamine (50% inhibitory concentration [IC50]) 2,000 nM) and cycloguanil (IC50 500 nM). Based on these susceptibility levels, 73 and 68 of 96 fresh clinical isolates were susceptible to pyrimethamine (mean IC50 15.4 nM) and cycloguanil (mean IC50 11.1 nM), respectively [1]. We tested pyrimethamine(previously reported to suppress SOD1 expression), several compounds currently in trials in human and murine ALS, and a set of 1040 FDA-approved compounds. In a PC12 cell-based assay, no compounds reduced SOD1 promoter activity without concomitant cytotoxicity. Additionally,pyrimethamine failed to repress levels of SOD1 protein in HeLa cells or homogenates of liver, spinal cord and brain of wild-type mice [3].in vivo: (131)I-Pyrimethamine (specific activity: 7.08 MBq/ mol) was injected intravenously into the tail vein of the control and infected rats. Static whole body images of the rats were acquired under the gamma camera at 5 min, 45 min, 2 h, 6 h, and 24 h following the intravenous administration of the radioactivity (3.7 MBq/rat) [2]. The 10-day treatment with 10mg/kg/day of fluconazole combined with 40/1mg/kg/day sulfadiazine and pyrimethamine resulted in 93% survival of CF1 mice acutely infected with the highly virulent T. gondii RH strain, versus 36% of mice treated with just sulfadiazine and pyrimethamine [4].Toxicity: Sulfadoxine/pyrimethamine is well tolerated as treatment and when used as intermittent preventive treatment in pregnant African women. Sulfadoxine/pyrimethamine is no longer used as prophylaxis because it may cause toxic epidermal necrolysis and Stevens Johnson syndrome [5]. 物理化学性质： CAS号：58-14-0 常用中文名：乙胺嘧啶常用英文名：pyrimethamine 分子式：C12H13ClN4 分子量：248.711 密度：1.4±0.1 g/cm3 沸点：368.4±52.0 °C at 760 mmHg 熔点：233-234°C 闪点：176.6±30.7 °C 储存条件：0-6°C

供应商信息：

公司名：广州佰瑞医药有限公司

认证状态： 未认证供应商

商品数： 169件

电话： 020-37651955

地址： 广州市海珠区新港中路397号自编76、77号B4-02

地区： 广州市海珠区

联系人： 刘鹏虎

联系人电话： 18028682016

邮件：dylan@gzbr.com.cn

网址：http://www.gzbr.com.cn/

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公司介绍：
佰瑞医药成立于2001年，是一家具GSP资质、以医药原料进出口、药品进口注册、一致性评价服务、原研参比制剂、PEG及其衍生物、BIA整体分离柱等为主要业务模块的医药产品供应链服务企业，秉持“诚信、专业、信任、高效”的经营理念及以“让世界爱上药品‘中国制造’”的使命，致力于推动药品“中国制造” 国际化，持续服务于国内的医药企业，将更多、更高性价比的优质产品和技术服务输送到中国。公司是多家国外知名药企在中国的授权总代理，拥有专业、高效的市场营销团队、技术团队和注册团队，团队成员均拥有药学相关专业背景，具丰富的国内外资源和网络，能够在业务开拓、采购销售、物流仓储、技术支持等环节给予客户最快速、最专业的一站式解决方案。

其他供应商价格：

2022-02-19 价格：￥102.9 乙胺嘧啶

2019-03-05 价格：￥668.0 乙胺嘧啶

2024-07-15 价格：需询单乙胺嘧啶

2018-01-31 价格：￥需询单乙胺嘧啶

2021-02-06 价格：￥619.0 Pyrimethamine

2017-10-18 价格：￥需询单乙胺嘧啶

2024-01-09 价格：$需询单 Pyrimethamine API

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乙胺嘧啶价格

乙胺嘧啶

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