葫芦素 B

产品详情：

更新时间： 2025-08-26 18:21:46

CAS号：6199-67-3

常用名： 葫芦素B

价格：
￥1200.0/20mg

纯度： 95.0%

备货期： 1天

库存： 900 mg

其他详情（用途，包装）：
用途： Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.IC50 value:Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulated expression of cell-cycle regulators in SHSY5Y cells. At the molecular level, we found that Cucurbitacin-B inhibited AKT signaling activation through up-regulation of PTEN [1]. CuB induced apoptosis of A549 cells in a -concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition [2]. CuB inhibited ITGA6 and ITGB4 (integrin α6 and integrin β4), which are overexpressed in breast cancer. Furthermore, CuB also induced the expression of major ITGB1and ITGB3, which are known to cause integrin-mediated cell death [3]. Cuc B treatment caused DNA double-strand breaks (DSBs) without affecting the signal transducer and activator of transcription 3 (STAT3), the potential molecular target for Cuc B. Cuc B triggers ATM-activated Chk1-Cdc25C-Cdk1, which could be reversed by both ATM siRNA and Chk1 siRNA. Cuc B also triggers ATM-activated p53-14-3-3-σ pathways, which could be reversed by ATM siRNA [4].in vivo: Efficacy of CuB was tested in vivo using two different orthotopic models of breast cancer. MDA-MB-231 and 4T-1 cells were injected orthotopically in the mammary fat pad of female athymic nude mice or BALB/c mice respectively. Our results showed that CuB administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%. The 4T-1 cells represent stage IV breast cancer and form very aggressive tumors [3]. 作用：葫芦素B对人胰腺Y细胞具有深远的体外和体内抗增殖作用。它通过上调PTEN抑制AKT信号激活。葫芦素B是一种有效的HIF-1抑制剂，为其抗癌活性机制提供了新的视角。葫芦素B在A549肺Y细胞中通过STAT3途径抑制抑制增殖并诱导细胞凋亡。物理化学性质： CAS号：6199-67-3 常用中文名：葫芦素B 常用英文名：Cucurbitacin B 分子式：C32H46O8 分子量：558.703 密度：1.2±0.1 g/cm3 沸点：699.3±55.0 °C at 760 mmHg 熔点：184-186ºC 闪点：218.8±25.0 °C 储存条件：库房低温,通风,干燥,与食品原料分开存放

供应商信息：

公司名：上海源叶生物科技有限公司

认证状态： 未认证供应商

商品数： 5711件

电话： 61559134

地址： 上海市松江区长塔路465号6幢

地区： 上海市松江区

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外贸占销售比例：

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公司介绍：
上海源叶生物科技有限公司是一家专门从事生物技术相关产品研发和销售的综合性生命科学公司，在全体员工的不懈努力和广大客户的大力支持下，公司迅速成长为一家拥有生物试剂部、实验部、生命科学仪器部以及技术服务部等部门的高新技术企业。公司地址：上海市杨浦区黄兴路1999号2号楼8E 我们的理念: 客户至上、服务至真；质量第一、诚信为本

其他供应商价格：

2024-09-29 价格：￥需询单葫芦素B

2022-03-04 价格：￥269.9 葫芦素B

2025-12-29 价格：￥需询单葫芦素B

2024-07-15 价格：需询单葫芦素B

2019-03-05 价格：￥1188.0 葫芦素B

2020-12-08 价格：￥4000.0 葫芦素B

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葫芦素 B

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