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Metformin hydrochloride

产品详情：

更新时间： 2020-04-04 07:37:29

CAS号：1115-70-4

常用名： 盐酸二甲双胍

价格：
$需询单/1kg

纯度： 99.9%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
Names
[ Name ]: Metformin Hydrochloride
[ Synonym ]: More Synonyms
Chemical & Physical Properties
[ Boiling Point ]: 224.1ºC at 760 mmHg
[ Melting Point ]: 223-226 °C(lit.)
[ Molecular Formula ]: C4H12ClN5
[ Molecular Weight ]: 165.625
[ Flash Point ]: 89.3ºC
[ Exact Mass ]: 165.078125
[ PSA ]: 88.99000
[ LogP ]: 1.05850
[ Vapour Pressure ]: 0.0929mmHg at 25°C
MSDS
Metformin hydrochloride MSDS(Chinese)
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
DU1800000
CHEMICAL NAME :
Biguanide, 1,1-dimethyl-, hydrochloride
CAS REGISTRY NUMBER :
1115-70-4
LAST UPDATED :
199801
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C4-H11-N5.Cl-H
MOLECULAR WEIGHT :
165.66
WISWESSER LINE NOTATION :
MUYZMYUM&N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,563,1982
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982
TYPE OF TEST :
Rinsed with water
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,934,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,934,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,841,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,841,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1193,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04012
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1193,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1193,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1193,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1193,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg/10D-C
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Vascular - BP lowering not characterized in autonomic section Related to Chronic Data - death
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 81,7,1997
Safety Information
[ Symbol ]: GHS07
GHS07
[ Signal Word ]: Warning
[ Hazard Statements ]: H302-H315-H319
[ Precautionary Statements ]: P305 + P351 + P338
[ Personal Protective Equipment ]: dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]: Xn
[ Risk Phrases ]: R22;R36/38
[ Safety Phrases ]: S26-S36
[ RIDADR ]: NONH for all modes of transport
[ WGK Germany ]: 3
[ RTECS ]: DU1800000
[ HS Code ]: 2925290090
Synthetic RouteTotal: 1 Page
metformin结构式
CAS#:657-24-9

metformin

~77%

Metformin hydrochloride Structure
CAS#:1115-70-4

Metformin hydro...

Literature: HANALL PHARMACEUTICAL COMPANY. LTD Patent: WO2008/93984 A1, 2008 ; Location in patent: Page/Page column 29 ;
Dimethylamine hydrochloride结构式
CAS#:506-59-2

Dimethylamine h...

N/A结构式
CAS#:127099-85-8

N/A

~94%

Metformin hydrochloride Structure
CAS#:1115-70-4

Metformin hydro...

Literature: Kelarev, V. I.; Bellul', M.; Zav'yalov, V. I.; Ammar Dibi; Golovin, A. N.; et al. Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 5 p. 994 - 998 Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 5 p. 1100 - 1105
Dimethylamine结构式
CAS#:124-40-3

Dimethylamine

N/A结构式
CAS#:127099-85-8

N/A

~%

Metformin hydrochloride Structure
CAS#:1115-70-4

Metformin hydro...

Literature: Pharmaceutical Chemistry Journal, , vol. 21, # 12 p. 892 - 894 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 12 p. 1517 - 1518
Precursor & DownStream
Precursor 3
metformin Structure CAS#:657-24-9
metformin
Dimethylamine hydrochloride Structure CAS#:506-59-2
Dimethylamine h...
Dimethylamine Structure CAS#:124-40-3
Dimethylamine
DownStream 4
6-(chloromethyl)-2-N,2-N-dimethyl-1,3,5-triazine-2,4-diamine structure CAS#:21320-37-6
6-(chloromethyl...
metformin structure CAS#:657-24-9
metformin
2-N,2-N-dimethyl-6-pyridin-3-yl-1,3,5-triazine-2,4-diamine structure CAS#:103261-85-4
2-N,2-N-dimethy...
6-heptadecyl-2-N,2-N-dimethyl-1,3,5-triazine-2,4-diamine structure CAS#:66740-79-2
6-heptadecyl-2-...
Customs
[ HS Code ]: 2925290090
[ Summary ]: 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
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Detail
Synonyms
Metformin HCl
1,1-Dimethylbiguanide hydrochloride,Metformin
3-(diaminomethylidene)-1,1-dimethylguanidine,hydrochloride
Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1)
1,1-Dimethylbiguanide hydrochloride
MFCD00012582
N,N-Dimethylimidodicarbonimidic diamide hydrochloride (1:1)
N1,N1-Dimethylbiguanide hydrochloride
Metformin hydrochloride
EINECS 214-230-6

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公司名：上海化源生化科技有限公司

区域：上海市普陀区

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联系人：徐经理

产品详情： 盐酸二甲双胍

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥118.0/100g ￥348.0/500g ￥138.0/200mg

联系人：刘佳

产品详情： 盐酸二甲双胍

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

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￥需询单/1g

联系人：赖经理

产品详情： Metformin HCl(Glucophage)

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥92.9/100g ￥39.9/10g ￥48.9/25g ￥266.9/500g

联系人：阿拉丁

产品详情： 二甲双胍盐酸盐

公司名：武汉敬康恩生物医药科技有限公司

区域：武汉市东西湖区

价格：
￥需询单/1g

联系人：周经理

产品详情： Metformin hydrochloride

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2024-07-15 价格：需询单 盐酸二甲双胍

2019-03-05 价格：￥118.0 盐酸二甲双胍

2022-11-29 价格：￥需询单 Metformin HCl(Glucophage)

2021-02-06 价格：￥489.0 Metformin HCl

2022-02-19 价格：￥92.9 二甲双胍盐酸盐

2023-11-18 价格：￥需询单 Metformin hydrochloride

2018-05-10 价格：￥150.0 盐酸二甲双胍

2016-10-28 价格：￥120.0 盐酸二甲双胍

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Metformin hydrochloride价格为$需询单/1kg, 由Metformin hydrochloride生产厂家济南德普顿斯化工科技有限公司提供，供应信息包括纯度，备货期/库存，供货能力等。>>电脑版：Metformin hydrochloride_价格_生产厂家【济南德普顿斯化工科技有限公司】

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