盐酸阿比多尔

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更新时间： 2024-03-08 15:28:45

CAS号：131707-23-8

常用名： 盐酸阿比朵尔

价格：
￥1300.0/1kg

纯度： 99.8%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
用途： Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membraneIC50 value:Target: Antiviral; Anti-influenza agentin vitro: Arbidol was found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with 50% inhibitory concentration (IC50) ranging from 2.7 to 13.8 microg/ml.However, arbidol showed selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5) [1]. Arb interacts with the polar head-group of phospholipid at the membrane interface. Fluorescence studies of interactions between Arb and either tryptophan derivatives or membrane peptides reconstituted into liposomes show that Arb interacts with tryptophan in the micromolar range. Interestingly, apparent binding affinities between lipids and tryptophan residues are comparable with those of Arb IC50 of the hepatitis C virus (HCV) membrane fusion [2]. Arbidol not only prevented the cytopathic effect (CPE) of CVB(5), as demonstrated in an MTT colorimetric assay, when added during or after viral infection, with a 50% inhibitory concentration (IC(50)) from 2.66 to 6.62 microg/ml, but it also decreased the CVB(5)-RNA level in infected host cells, as shown in semi-quantitative RT-PCR [3].in vivo: Orally administered arbidol at 50 or 100 mg/kg/day beginning 24 h pre-virus exposure for 6 days significantly reduced mean pulmonary virus yields and the rate of mortality in mice infected with FLU-A (A/PR/8/34 H1N1) [1]. BALB/c mice were used as an animal model to test the Arbidol activity in vivo. Orally administered Arbidol at 50 mg/kg body weight/day (once a day) significantly reduced mean virus yields in the lungs and heart as well as mortality after infection for 6 days [3]. 作用：据长江日报消息，中国工程院院士、国家卫健委高级别专家组成员李兰娟团队在武汉公布治疗新型冠状病毒感染的肺炎的最新研究成果。李兰娟院士说，根据初步测试，在体外细胞实验中显示：（1）阿比朵尔在10～30微摩尔浓度下，与药物未处理的对照组比较，能有效抑制冠状病毒达到60倍，并且显著抑制病毒对细胞的病变效应。（2）达芦那韦在300微摩尔浓度下，能显著抑制病毒复制，与未用药物处理组比较，抑制效率达280倍。她建议将以上两种药物列入国家卫健委《新型冠状病毒感染的肺炎诊疗方案(试行第六版)》。物理化学性质： CAS号：131707-23-8 常用中文名：盐酸阿比朵尔常用英文名：Arbidol HCl 分子式：C22H26BrClN2O3S 分子量：513.875 密度：N/A 沸点：591.8ºC at 760 mmHg 熔点：133-137ºC 闪点：311.7℃ 储存条件：Hygroscopic, Refrigerator, Under Inert Atmosphere

供应商信息：

公司名：石家庄青禾生物科技有限公司

认证状态： 未认证供应商

商品数： 16件

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2024-07-15 价格：需询单盐酸阿比朵尔水合物

2024-09-13 价格：￥需询单盐酸阿比朵尔

2024-03-12 价格：￥需询单盐酸阿比朵尔

2017-07-07 价格：￥需询单盐酸阿比朵尔

2017-09-13 价格：￥需询单盐酸阿比多尔

2021-02-06 价格：￥489.0 Arbidol HCl

2017-07-01 价格：￥需询单盐酸阿比朵尔

2024-04-30 价格：￥需询单盐酸阿比朵尔

2022-03-23 价格：$需询单 Arbidole HCl

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