3'3'-cGAMP (sodium salt)

产品详情：

更新时间： 2025-12-20 21:40:19

CAS号：849214-04-6

常用名： cGAMP

价格：
$350.0/5mg $990.0/25mg $550.0/10mg

纯度： 98.0%

备货期： 3天

库存： 3

产品页： https://www.dcchemicals.com/product_show-849214-04-6.html

其他详情（用途，包装）：
3’3’-cGAMP Fluorinated (c-[2'FdGMP]-[2'FdAMP]) is a synthetic analog of cyclic guanosine monophosphate- adenosine monophosphate (cyclic GMP-AMP, cGAMP) with a fluorine atom at 2’ position of the nucleosides. 3’3’-cGAMP is a cyclic di-nucleotide produced by bacteria. It is also referred to as "canonical" cGAMP due the presence of the classical 3’-5’ phosphodiester linkages between the guanosine and the adenosine. It has been reported that cGAMP binds STING (stimulator of IFN genes) and subsequently induces TBK1-IRF3-dependent production of IFN-β [1].

The incorporation of fluorine into biologically active molecules is commonly used in medicinal chemistry to improve their metabolic stability or to modulate physicochemical properties such as lipophilicity [2, 3]. Moreover, the introduction of a fluorine atom can change the biological activities of a molecule. Interestingly, when used at low concentrations in various cellular assays, 3’3’-cGAMP Fluorinated induces higher levels of type I IFNs than does cGAMP.

STING ligands such as cGAMP induce type I IFNs and activate interferon stimulated genes (ISG) through IRFs. To facilitate their study, InvivoGen has developed stable reporter cells in two well established immune cell models: THP-1 human monocytes and RAW 264.7 murine macrophages. These cells express a reporter gene (SEAP or Lucia luciferase), under control of an IRF-inducible promoter.

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D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.

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其他供应商价格：

2022-03-04 价格：￥3299.9 cGAMP

2024-07-15 价格：需询单 cGAMP游离态

2021-02-06 价格：￥1094.0 3'3'-cGAMP

2022-05-12 价格：$需询单 cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP)

2021-05-10 价格：￥需询单 C-GPAP

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cGAMP价格

3'3'-cGAMP (sodium salt)

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