甲磺酸依普罗沙坦

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更新时间： 2025-09-18 20:02:53

CAS号：144143-96-4

常用名： 甲磺酸依普罗沙坦

价格：
￥需询单/1mg

纯度： 98.0%

备货期： 3天

库存： 现货

其他详情（用途，包装）：
用途： Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively. IC50 Value: 9.2 nM(in rat adrenal cortical membranes); 3.9 nM(in human adrenal cortical membranes)Target: Angiotensin Receptor Type-1(AT1)in vitro: Eprosartan mesylate, is one of the highly selective, orally active, non-peptide angiotensin-II-receptor antagonists [1]. In rat and human adrenal cortical membranes, Eprosartan displaced specifically bound [125I]AII with IC50 of 9.2 and 3.9 nM, respectively. Eprosartan also inhibited [125I]AII binding to human liver membranes (IC50 = 1.7 nM) and to rat mesenteric artery membranes (IC50 = 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca++ levels. In rabbit aortic rings [2].in vivo: Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr. In this same rat model, Eprosartan had no effect on base-line pressure or on the pressor response to norepinephrine or vasopressin [2]. Eprosartan is highly effective and safe in lowering blood pressure, notably SBP, in older subjects with mild to moderate hypertension [3]. Treatment with eprosartan in once-daily doses up to 1200 mg alone or in combination with HCTZ was well tolerated, with dizziness and asthenia being the most common side effects [4]. Therapy with eprosartan mesilat was associated with significant hypotensive effect (more evident in patients with high systolic blood pressure), improvement in 24-hour blood pressure profile and quality of life, and lower probability of secondary stroke. Side effects were not observed [5]. 物理化学性质： CAS号：144143-96-4 常用中文名：甲磺酸依普罗沙坦常用英文名：Eprosartan mesylate 分子式：C24H28N2O7S2 分子量：520.618 密度：1.26 g/cm3 沸点：660.6ºC 熔点：248 °C 闪点：353.3ºC 储存条件：room temp

供应商信息：

公司名：上海泽涵生物医药科技有限公司

认证状态： 未认证供应商

商品数： 1060件

电话： 021-61350663

地址： 上海浦东新区丽正路1628号4幢4045室

地区： 上海市浦东新区

联系人： 薛经理

联系人电话： 13052117465

邮件：sales@zehanbiopharma.com

网址：http://www.zehanbiopharma.com

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公司介绍：
上海泽涵生物医药科技有限公司是集医药化学品（含中间体）、精细化学品和生物医药产品的研究、开发、生产、产品销售、技术服务于一体的高新企业。

其他供应商价格：

2022-02-19 价格：￥616.9 依普罗沙坦甲磺酸盐

2024-07-15 价格：需询单 (E)-4-((2-丁基-5-(2-羧基-3-(噻吩-2-基)丙-1-烯-1-基)-1H-咪唑-1-基)甲基)苯甲酸甲磺酸盐

2019-03-05 价格：￥698.0 依普罗沙坦甲磺酸盐

2022-09-16 价格：￥1350.0 甲磺酸依普罗沙坦

2023-10-16 价格：$需询单 Eprosartan mesylate

2018-04-11 价格：￥需询单甲磺酸依普罗沙坦

2024-07-23 价格：￥3800.0 莱克多巴胺

2021-02-06 价格：￥489.0 Eprosartan Mesylate

2023-03-17 价格：￥13.0 甲磺酸依普罗沙坦

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