GLPG 0492
产品详情：
发布时间： 2021-07-26 18:31:21
CAS号：1215085-92-9
常用名：
价格：
$需询单/100g
$需询单/1kg
$需询单/100kg
$需询单/1000kg
纯度： 98.0%
备货期： 需询单
库存： 询单
其他详情（用途，包装）：
用途： GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.IC50 value:Target: AR modulatorGLPG0492 has very good pharmacokinetic properties, including bioavailability in rat (F > 50%), and is currently under evaluation in phase I clinical trials [1]. GLPG0492 is a new non-steroidal selective androgen receptor modulator that is currently under development for musculo-skeletal diseases such as sarcopenia and cachexia. In acute exhaustion tests, a surrogate of the 6-min walking test used in DMD patients, GLPG0492 preserved running performance, whereas vehicle- or comparator-treated animals showed a significant increase in fatigue (30-50%) [2]. GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. Interestingly, GLPG0492 was found as efficacious as TP at reducing muscle loss while sparing reproductive tissues. Furthermore, gene expression studies performed on tibialis samples revealed that both GLPG0492 and TP were slowing down muscle loss by negatively interfering with major signaling pathways controlling muscle mass homeostasis [3]. 物理化学性质： CAS号：1215085-92-9 常用中文名：GLPG0492 常用英文名：GLPG0492 分子式：C19H14F3N3O3 分子量：389.328 密度：1.5±0.1 g/cm3 沸点：544.0±60.0 °C at 760 mmHg 熔点：N/A 闪点：282.8±32.9 °C 储存条件：2-8℃
供应商信息：
公司名：达阳化工（杭州）有限公司 推荐
认证状态： 已认证供应商
商品数： 50181件
电话： +86571-88938639
地址： 浙江省杭州市西湖区文三路259号2栋9楼
地区： 杭州市西湖区
联系人： 王小姐
联系人电话： +86-571-8893-8639
邮件：enquiry@dycnchem.com
主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
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其他供应商价格：
2021-04-03 价格：￥4635.0
2022-11-22 价格：$需询单
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相关产品价格：
GLPG 0492价格为$需询单/100g, 由GLPG 0492生产厂家达阳化工（杭州）有限公司提供，供应信息包括纯度，备货期/库存，供货能力等。>>电脑版：GLPG 0492_价格_生产厂家【达阳化工（杭州）有限公司】
标题：GLPG 0492 - 生产厂家：达阳化工（杭州）有限公司 地址：https://m.chemsrc.com/mip/chanpin/4338598.html