2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

产品详情：

发布时间： 2021-07-26 18:31:34

CAS号：36341-25-0

常用名： 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： YL-109 is a novel anticancer agent which has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.IC50 value: 85.7 nM(MCF-7 cells proliferation) [1]Target: AhR signaling activcatorin vitro: YL-109 strongly inhibited cell proliferation of MCF-7 cells in a dose-dependent manner (IC50= 85.8 nM). Surprisingly, YL-109 had an anti-proliferative effect in a dose-dependent manner (IC50 = 4.02 μM) on MDA-MB-231 cells. YL-109 repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures. YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein (CHIP), which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway. YL-109 induced CHIP transcription because of the recruitment of the aryl hydrocarbon receptor (AhR) to upstream of CHIP gene in MDA-MB-231 cells. Consistently, the antitumor effects of YL-109 were depressed by CHIP or AhRknockdown in MDA-MB-231 cells [1].in vivo: Mice treated with vehicle showed significantly enlarged tumors, whereas mice treated with YL-109 showed attenuated tumor growth using MCF-7 cells. Interestingly, YL-109 also suppressed tumor growth in mice injected with MDA-MB-231 cells. Compared with the vehicle control, YL-109 significantly reduced lung metastasis [1]. 物理化学性质： CAS号：36341-25-0 常用中文名：4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚常用英文名：YL-109 分子式：C14H11NO2S 分子量：257.30800 密度：1.327g/cm3 沸点：446.448ºC at 760 mmHg 熔点：N/A 闪点：223.804ºC 储存条件：2-8°C，密闭，干燥

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50185件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2024-07-15 价格：需询单 2-(4-羟基-3-甲氧基苯基)苯并噻唑

2022-11-29 价格：￥需询单 YL-109

2021-02-06 价格：￥789.0 YL-109

2025-09-17 价格：￥需询单 2-(4-羟基-3-甲氧基苯基)苯并噻唑

2024-03-12 价格：￥1159.9 YL-109

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4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚价格

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

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