Rosuvastatin calcium

产品详情：

发布时间： 2021-07-26 18:31:53

CAS号：147098-20-2

常用名： 瑞舒伐他汀钙

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. IC50 Value: 11 nM [1]Target: HMG-CoA reductasein vitro: Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM [2]. Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin [1]. Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells [3].in vivo: Rosuvastatin (3 mg/kg) daily administration for 14 days decreases plasma cholesterol levels by 26% in male beagle dogs with normal cholesterol levels. In cynomolgus monkeys, Rosuvastatin decreases plasma cholesterol levels by 22% [1]. Rosuvastatin (20 mg/kg/day) administration for 2 weeks, significantly reduces very low-density lipoproteins (VLDL) in diabetes mellitus rats induced by Streptozocin [4]. Rosuvastatin shows antiatherothromhotic effects in vivo. Rosuvastatin (1.25 mg/kg) significantly inhibits thrombin-induced transmigration of monocvtes across mesenteric venules via inhibition of the endothelial cell surface expression of P-selectin, and increases the basal rate of nitric oxide in aortic segments by 2-fold times [5]. 物理化学性质： CAS号：147098-20-2 常用中文名：瑞舒伐他汀钙常用英文名：Rosuvastatin Calcium 分子式：C22H27Ca0.5FN3O6S 分子量：500.57 密度：N/A 沸点：745.6ºC at 760 mmHg 熔点：122ºC 闪点：404.7ºC 储存条件：-20°C Freezer

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

主要合作伙伴：

公司介绍：

其他供应商价格：

2024-07-15 价格：需询单瑞舒伐他汀钙

2022-02-19 价格：￥63.9 瑞舒伐他汀钙

2018-05-14 价格：￥需询单瑞舒伐他汀钙

2017-07-08 价格：￥需询单瑞舒伐他汀钙

2017-08-06 价格：￥需询单瑞舒伐他汀钙

2021-03-03 价格：￥需询单瑞舒伐他汀钙

2018-07-26 价格：$需询单 Rosuvastatin Calcium

2017-06-18 价格：￥需询单瑞舒伐他汀钙

2022-10-19 价格：￥需询单舒伐他汀钙

2020-12-08 价格：￥1360.0 瑞舒伐他汀钙

查看所有价格请点击：

瑞舒伐他汀钙价格

Rosuvastatin calcium

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：