Embelin

产品详情：

更新时间： 2025-11-04 14:52:43

CAS号：550-24-3

常用名： 恩贝灵；恩贝酸

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide).IC50 value: 4.1 uM [1]Target: XIAPin vitro: Embelin induced activation of caspase-9 and embelin-induced apoptosis was prevented by caspase inhibitors [2]. Treatment with subtoxic doses of Embelin broadly sensitized malignant glioma cells to TRAIL-mediated apoptosis. Notably, human astrocytes were not significantly affected by the combined treatment consisting of Embelin and TRAIL. Combined treatment with Embelin and TRAIL augmented the activation of initiator caspases-8/-9 and effector caspases-3/-7, respectively [3]. in vivo: Embelin inhibited topical edema in the mouse ear, leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, embelin was effective at reducing inflammatory damage induced by chronic TPA exposure [4]. Embelin (10, 30 or 50mg/kg body weight) was administrated daily per oral route for 7days. Embelin significantly attenuated DSS-induced DAI scores and tissue MPO accumulation, which implied that it suppressed weight loss, diarrhea, gross bleeding, and the infiltrations of immune cells. Embelin administration also effectively and dose-dependently prevented shortening of colon length and enlargement of spleen size [5]. 物理化学性质： CAS号：550-24-3 常用中文名：恩贝灵；恩贝酸常用英文名：Embelin 分子式：C17H26O4 分子量：294.386 密度：1.131 沸点：431.9±45.0 °C at 760 mmHg 熔点：145-146 ºC 闪点：229.1±25.2 °C 储存条件：Store at +4°C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

主要合作伙伴：

公司介绍：

其他供应商价格：

2024-09-29 价格：￥需询单恩贝酸

2024-03-12 价格：￥1366.9 恩贝酸

2024-07-15 价格：需询单酸藤子酚

2019-03-05 价格：￥688.0 酸藤子酚

2016-10-30 价格：￥需询单恩贝酸/恩贝灵

2020-12-08 价格：￥1889.0 恩贝灵

查看所有价格请点击：

恩贝灵；恩贝酸价格

Embelin

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