1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE

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更新时间： 2023-02-23 15:26:35

CAS号：79183-19-0

常用名： MDK83190

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$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 exerted a cytotoxic effect, reducing the cell numbers by 10–50% and 50–100% in four and eight cell lines, respectively, from the initial levels when tested at 10 μM. At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines, an effect that may be due to nonspecific toxicity. Of the cancer cell lines tested in the panel, cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) were quite sensitive to compound 2-induced killing, with IC50 values ranging from 4 to 9 μM [1]. Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively, also has less inhibition on AChE/BChE with Ki of 48.2/12.6 uM [2]. 物理化学性质： CAS号：79183-19-0 常用中文名：MDK83190 常用英文名：Apoptosis Activator 2 分子式：C15H9Cl2NO2 分子量：306.143 密度：1.5±0.1 g/cm3 沸点：470.6±55.0 °C at 760 mmHg 熔点：N/A 闪点：238.4±31.5 °C 储存条件：Store at RT

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公司名：达阳化工（杭州）有限公司推荐

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其他供应商价格：

2022-02-19 价格：￥303.9 1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮

2020-12-08 价格：￥2149.0 MDK83190

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MDK83190价格

1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE

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