1-(2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL)-5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-2(3H)-ONE

产品详情：

更新时间： 2022-01-28 17:32:46

CAS号：153587-01-0

常用名： 1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[d]咪唑-2(3h)-酮

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： NS-1619 is a selective large conductance Ca2+-activated K+-channel activator.IC50 value: Target: Ca2+-activated K+-channel activatorNS 1619 (3-100 microM) produced a concentration-dependent inhibition of spontaneous activity in rat portal vein characterized by a reduction in the amplitude and duration of the tension waves. This inhibition was slightly potentiated in the presence of either charybdotoxin (250 nM) or penitrem A (1 microM) [1]. NS-1619 induced concentration-dependent activation of BKCa channels with a calculated EC50 of 32 microM. The NS 1619-induced activity was dependent on the presence of free Ca2+ at the intracellular surface, but was not associated with a change in channel voltage sensitivity [2]. NS 1619 (50 microM) inhibited the noradrenaline-induced contraction. NS 1619 (10-100 microM) reduced the high K+-induced contractions in a noncompetitive manner [3]. Inhalation of a 12 μM and 100 μM NS1619 solution significantly reduced RV pressure without affecting systemic arterial pressure. Blood gas analyses demonstrated significantly reduced carbon dioxide and improved oxygenation in NS1619-treated animals pointing towards a considerable pulmonary shunt-reducing effect. In PASMC's, NS1619 (100 μM) significantly attenuated PASMC proliferation by a pathway independent of AKT and ERK1/2 activation [4]. 物理化学性质： CAS号：153587-01-0 常用中文名：1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[d]咪唑-2(3h)-酮常用英文名：NS-1619 分子式：C15H8F6N2O2 分子量：362.22700 密度：1.563g/cm3 沸点：N/A 熔点：234 °C(dec.) 闪点：N/A 储存条件：存放于惰性气体之中;避免空气

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 48306件

电话： +86571-88938639

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联系人： 王小姐

联系人电话： +86-571-8893-8639

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2022-02-19 价格：￥294.9 NS-1619

2025-09-17 价格：￥需询单 1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H苯并[d]咪唑-2(3H)-酮

2024-07-15 价格：需询单 1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H苯并[d]咪唑-2(3H)-酮

2021-02-06 价格：￥1069.0 NS 1619

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1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[d]咪唑-2(3h)-酮价格

1-(2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL)-5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-2(3H)-ONE

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