(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

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更新时间： 2024-04-07 17:51:45

CAS号：1384426-12-3

常用名： (E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： NT157is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) .IC50 value: 0.3 to 0.8 μM [1]Target: Insulin receptorin vitro: NT157 significantly affects the cells' migratory ability, as confirmed by a wound-healing assay. NT157 induces cytostatic effects, as evidenced by G2/M cell cycle arrest, and does not affect apoptosis. NT157, a novel small-molecule that specifically targets IRS protein, in OS cells. NT157 is a small-molecule inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1 and IRS-2. NT157 efficiently affects migration ability of MG-63 and U-2OS OS cells. NT157 treatment induces cell cycle arrest and inhibits IGF system signaling. [1] The density of LNCaP cells grown in FBS was decreased approximately 20% at 1 μM, approximately 70% at 2 μM, and >90% at 5 μM (IC50, 1.4 μM). Growth of LNCaP cells is suppressed >60% when cultured in CSS but still exhibited significant density at 2 μM and maximal decreased density at 5 μM. The density of FBS-cultured PC3 cells was similarly decreased by NT157 treatment (40% at 2 μM and > 70% at 5 μM; IC50, 2.5 μM). [2]in vivo: NT157 suppresses growth of LNCaP xenografts following castration. NT157 treatment affects IGF1R and IRS targets in xenografts and significantly delays castration-resistant progression of LNCaP androgen-responsive xenografts when combined with castration. NT157 potentiates docetaxel activity in PC3 xenografts.[2] 物理化学性质： CAS号：1384426-12-3 常用中文名：(E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺常用英文名：NT157 分子式：C16H14BrNO5S 分子量：412.255 密度：1.8±0.1 g/cm3 沸点：660.3±65.0 °C at 760 mmHg 熔点：N/A 闪点：353.1±34.3 °C 储存条件：-20°C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2024-07-15 价格：需询单 NT157

2022-11-29 价格：￥需询单 NT-157

2021-02-06 价格：￥1509.0 NT157

2022-03-04 价格：￥499.9 NT157

2017-12-15 价格：￥需询单 NT-157

2023-09-22 价格：￥需询单 NT157

2021-05-10 价格：￥需询单 NT-157

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(E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺价格

(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

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