Ropinirole hydrochloride

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更新时间： 2023-10-07 15:50:19

CAS号：91374-20-8

常用名： 盐酸罗匹尼罗

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Ropinirole hydrochloride(SKF101468 hydrochloride) a selective dopamine D2 receptor inhibitor with IC50 of 29 nM.Target: Dopamine D2 ReceptorRopinirole (50 mg/kg, i.p.) causes biphasic spontaneous locomotor activity in mice. Ropinirole (0.05-1.0 mg/kg SC) dose-dependently inhibits the dyskinesias induced by 2-di-n-propylamino-5,6-di-hydroxytetralin in mice. Ropirtirole, at doses of 1 and 10 μg, injected unilaterally directly into the striatum of the rat causes marked, contralateral (away from the side of injection) asymmetry and circling in mice. Ropinirole (0.05-1.0 mg/kg SC or 0.1 mg/kg PO) reverses all motor and behavioural deficits induced by MPTP in marmosets [1]. Ropinirole (2 mg/kg, i.p.) for 7 days increases GSH, catalase and SOD activities in the striatum and protected striatal dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in mice [2]. Ropinirole (0.2 mg/kg, i.p.) improves the use of previously akinetic forelimb and produced robust circling behavior in lesioned rats with striatal over-expression of both D2R and D3R compared to lesioned animals that received blank vector. The subtherapeutic dose of ropinirole generates only modest motor effects in lesioned rats with sole over-expression of D2R or D3R [3]. Ropinirole (1-8 mg t.i.d.) is rapidly and completely absorbed with oral bioavailability of 55%, clearance of 780 mL/min, elimination half-life of 6 hours in healthy volunteer. Since the major route of elimination for Ropinirole is by the CYP enzyme system, mainly by CYP1A2 and also by CYP3A4, inhibition of the former and possibly the latter may reduce the agent's clearance and lead to drug accumulation [4]. 物理化学性质： CAS号：91374-20-8 常用中文名：盐酸罗匹尼罗常用英文名：Ropinirole hydrochloride 分子式：C16H25ClN2O 分子量：296.836 密度：N/A 沸点：410.5ºC at 760mmHg 熔点：241-243ºC 闪点：N/A 储存条件：Room temp

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2022-03-04 价格：￥317.9 盐酸罗匹尼罗

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2022-09-16 价格：￥500.0 盐酸罗匹尼罗

2018-05-12 价格：￥需询单盐酸罗匹尼罗

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2022-01-14 价格：￥需询单盐酸罗匹尼罗

2021-02-06 价格：￥439.0 Ropinirole HCl

2022-05-12 价格：$需询单 Ropinirole HCl

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盐酸罗匹尼罗价格

Ropinirole hydrochloride

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