EMD-1214063

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更新时间： 2022-02-13 17:18:54

CAS号：1100598-32-0

常用名： 特泊替尼

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. IC50 Value: 4 nM [1]Target: c-Metin vitro: EMD 1214063 inhibits HGF-induced c-Met phosphorylation in A549 cells with IC50 of 6 nM. Treatment with EMD 1214063 induces a marked reduction of c-Met–constitutive phosphorylation in EBC-1 cells with IC50 of 9 nM. EMD 1214063 effectively blocka phosphorylation of the major downstream effectors of the c-Met enzyme, such as Grb2, Gab1, Sos, PLCγ, and phosphoinositide 3-kinase, in EBC-1, MKN-45, and Hs746T cells in the range of 1 to 10 nM. EMD 1214063 considerably inhibits the viability of MKN-45 cells with IC50 of less than 1 nM. Treatment with EMD 1214063 (as low as 0.1 nM) inhibits HGF-induced NCI-H441 cell migration, whereas concentrations of 100 nM to 1 μM almost completely prevents it.in vivo: EMD 1214063 treatment, at doses of 10 mg/kg or more, results in more than 90% inhibition of c-Met phosphorylation in Hs746T xenograft tumor for a period of at least 72 hours. EMD 1214063 induces more than 50% reduction of cyclin D1 expression, which persists after 96 hours upon treatment with doses of 100 mg/kg. A transient induction of p27 and cleaved caspase-3 are also observed upon treatment with EMD 1214063. EMD 1214063 (15 mg/kg, daily) treatment induces complete regression of gastric carcinoma xenografts Hs746T, in which c-Met is amplified, overexpressed, and activated in a ligand-independent fashion. 物理化学性质： CAS号：1100598-32-0 常用中文名：特泊替尼常用英文名：tepotinib 分子式：C29H28N6O2 分子量：492.572 密度：1.3±0.1 g/cm3 沸点：626.5±65.0 °C at 760 mmHg 熔点：N/A 闪点：332.7±34.3 °C 储存条件：-20℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2022-03-04 价格：￥5199.9 特泊替尼

2024-07-15 价格：需询单 EMD1214063

2025-09-17 价格：￥需询单 EMD 1214063

2024-01-12 价格：￥需询单 Tepotinib

2022-05-12 价格：$需询单 Tepotinib(EMD-1214063)

2020-12-08 价格：￥807.5 特泊替尼（EMD 1214063）

2018-04-15 价格：￥需询单 EMD1214063

2023-08-30 价格：￥需询单 EMD1214063

2023-11-13 价格：￥需询单特泊替尼

2021-05-10 价格：￥需询单 Tepotinib(EMD 1214063)

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特泊替尼价格

EMD-1214063

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