ANDROGRAPHOLIDE, DEOXY-

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更新时间： 2022-02-12 12:04:29

CAS号：79233-15-1

常用名： 去氧穿心莲内酯

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Deoxyandrographolide is a natural compound extracted from A. paniculata; potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells.IC50 value:Target: Anticancer natural compoundin vitro: Treatment with 14-DAG activated AMPK through induction of cyclic AMP-protein kinase A pathway. 14-DAG controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. In conclusion, our results indicated that 14-DAG was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism [1]. 14-DAG down-regulated the formation of death-inducing signalling complex, resulting in desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway [2]. 14-DAP, in concentrations between 10-100 microM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAP reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) [3]. in vivo: Half of the ethanol-fed animals received 14-deoxyandrographolide (14-DAG) treatment for the last 4 weeks of study. protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism [4]. 物理化学性质： CAS号：79233-15-1 常用中文名：去氧穿心莲内酯常用英文名：Deoxyandrographolide 分子式：C20H30O4 分子量：334.450 密度：1.1±0.1 g/cm3 沸点：511.7±50.0 °C at 760 mmHg 熔点：N/A 闪点：178.2±23.6 °C 储存条件：2-8℃

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公司名：达阳化工（杭州）有限公司推荐

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年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2019-03-05 价格：￥3438.0 去氧穿心莲内酯

2025-12-29 价格：￥需询单去氧穿心莲内酯

2024-07-15 价格：需询单去氧穿心莲内酯

2021-02-06 价格：￥4680.0 Deoxyandrographolide

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去氧穿心莲内酯价格

ANDROGRAPHOLIDE, DEOXY-

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