Ursolic acid

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更新时间： 2022-02-12 15:37:23

CAS号：77-52-1

常用名： 熊果酸

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Ursolic acid(Bungeolic acid) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. IC50 value:Target:in vitro: UA induced phosphorylation of AMP-activated protein kinase alpha (AMPKα) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner [1]. The combination of ursolic acid (0.5 μM) and leucine (10 μM) proved to be the most effective in promoting myogenic differentiation. The combination of ursolic acid and leucine significantly increased CK activity than treatment with either agent alone. The level of myosin heavy chain, a myogenic differentiation marker protein, was also enhanced by the combination of ursolic acid and leucine [2]. Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3. Furthermore, the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase was increased by the administration of ursolic acid. In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells and significantly decreased the expression of matrix metalloproteinase (MMP)-2 [3]. ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis [4].in vivo: UA treatment markedly improved the survival of septic rats, and attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, infiltration of leukocytes and proteins, myeloperoxidase activity, and malondialdehyde content. In addition, UA significantly decreased the serum levels of tumor necrosis factor-α, interleukin-6, and interleukin-1β, inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lung, which are involved in the productions of nitric oxide and prostaglandin E2 [5]. 作用：熊果酸具有抗癌、抗菌、抗炎、降血清转氨酶、降温和安定等作用；可作为药物、食品的乳化剂；动物试验证明，熊果酸具有抗糖尿病作用，对正常小鼠巨噬细胞的吞噬功能有明显增强作用。物理化学性质： CAS号：77-52-1 常用中文名：熊果酸常用英文名：Ursolic Acid 分子式：C30H48O3 分子量：456.700 密度：1.1±0.1 g/cm3 沸点：556.9±50.0 °C at 760 mmHg 熔点：292 °C (dec.)(lit.) 闪点：304.7±26.6 °C 储存条件：2~8°C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

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其他供应商价格：

2024-09-29 价格：￥需询单熊果酸

2022-02-19 价格：￥205.9 熊果酸

2019-03-05 价格：￥348.0 熊果酸

2026-03-10 价格：￥需询单熊果酸

2024-02-29 价格：￥270.0 熊果酸

2024-07-15 价格：需询单熊果酸

2025-01-03 价格：￥需询单熊果酸

2018-05-02 价格：￥260.0 熊果酸

2017-04-20 价格：￥150.0 熊果酸

2017-12-09 价格：￥需询单熊果酸

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熊果酸价格

Ursolic acid

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