6-(octylamino)pyrimidine-2,4(1H,3H)-dione

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发布时间： 2021-07-26 18:31:49

CAS号：83797-69-7

常用名： GTPL5846

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： 6-OAU(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.IC50 value: 105 nM [1]Target: GPR84 agonistin vitro: 6-OAU increased [35S]GTPγS incorporated in Sf9 cell membranes expressing human GPR84-Gαi fusion protein with an EC50 of 512 nM. 6-OAU did not activate human GPR40 in HEK293 cells in the PI assay. Stimulation with 6.25 μm 6-OAU began to induce GPR84-EGFP internalization, and the extensive internalization was observed at 200 μm 6-OAU stimulation. In a Transwell assay, 3-OH-C12 and the surrogate agonist, 6-OAU, provoked chemotaxis of PMNs prepared from human peripheral blood in a concentration-dependent manner with an EC50 of 24.2 μm and 318 nm, respectively. In addition, 3-OH-C12 and 6-OAU increased the secretion of IL-8 from LPS-stimulated PMNs [1].in vivo: Injection of 6-OAU suspension in 1% rat serum into the rat jugular vein (10 mg/kg) leads to the elevation of a chemokine, CXCL1 concentration in the serum peaking at 3 h after the injection. In the rat air pouch model, 6-OAU at 1 mg/ml dissolved in 0.3% BSA attracted both PMNs and macrophages into the air pouch, peaking at 4 h after 6-OAU inoculation [1]. 物理化学性质： CAS号：83797-69-7 常用中文名：GTPL5846 常用英文名：6-OAU 分子式：C12H21N3O2 分子量：239.314 密度：1.1±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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外贸占销售比例：90%

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其他供应商价格：

2024-03-12 价格：￥947.9 6-OAU

2024-07-15 价格：需询单 GTPL5846

2021-02-06 价格：￥1193.0 6-OAU

2023-10-18 价格：￥需询单 6-OAU

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GTPL5846价格

6-(octylamino)pyrimidine-2,4(1H,3H)-dione

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