Corosolic acid

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更新时间： 2023-11-17 15:24:46

CAS号：4547-24-4

常用名： 科罗索酸

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$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Corosolic acid isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity.IC50 value: 26.8 μg/ml in vitroTarget:In vitro: Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose-dependent pattern in an in vitro PKC assay [1]. MTT method was used to detect the influence of corosolic acid on A549 lung cancer cell growth in vitro under different concentrations. The value of IC50 was 26.8 μg/ml in vitro experiment. Corosolic acid of different doses had certain therapeutic effects on A549 solid tumor, the content of VEGF and CD34 proteins also had different degrees of influence [2]. Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. It inhibited the proliferation and tube formation of human umbilical vein endothelial cells and human dermal lymphatic microvascular endothelial cells, decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1 [3]. In vivo: A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid. 物理化学性质： CAS号：4547-24-4 常用中文名：科罗索酸常用英文名：Corosolic acid 分子式：C30H48O4 分子量：472.700 密度：1.1±0.1 g/cm3 沸点：573.3±50.0 °C at 760 mmHg 熔点：N/A 闪点：314.6±26.6 °C 储存条件：2-8°C

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公司名：达阳化工（杭州）有限公司推荐

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其他供应商价格：

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2022-07-06 价格：￥需询单科罗索酸

2021-02-06 价格：￥2099.0 Corosolic Acid

2025-07-24 价格：￥需询单科罗索酸

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科罗索酸价格

Corosolic acid

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