AKR 501

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更新时间： 2023-10-10 21:57:17

CAS号：570406-98-3

常用名： 马来酸阿伐曲波帕

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Avatrombopag(AKR-501; AS1670542) is a novel orally-active thrombopoietin(TPO) receptor agonist with EC50 of 3.3 nM.EC50 value: 3.3 nM [1]Target: TPO receptor agonistin vitro: AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501, however, was shown to be effective only in humans and chimpanzees with high species specificity [1]. AS1670542 has 50% effective concentration values for cell proliferation with AS1670542 or eltrombopag were 1.9 and 13nM, respectively, while those for megakaryocyte colony formation from human cord blood CD34(+) cells with AS1670542 or eltrombopag were 260 and 950nM, respectively [2].in vivo: Daily oral administration of AKR-501 dose-dependently increased the number of human platelets in in human platelet producing non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice transplanted with human fetal liver CD34(+) cells, with significance achieved at doses of 1 mg/kg and above. The peak unbound plasma concentrations of AKR-501 after administration at 1 mg/kg in NOD/SCID mice were similar to those observed following administration of an active oral dose in human subjects [1]. AS1670542 significantly increased the number of human platelets in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice with transplanted human hematopoietic stem cells at 0.3 (P 物理化学性质： CAS号：570406-98-3 常用中文名：马来酸阿伐曲波帕常用英文名：avatrombopag 分子式：C29H34Cl2N6O3S2 分子量：649.655 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2024-03-12 价格：￥482.9 阿伐曲泊帕

2024-07-15 价格：需询单 Avatrombopag

2017-10-27 价格：￥需询单 Avatrombopag

2021-08-09 价格：$需询单 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid

2021-04-03 价格：￥3416.0 Avatrombopag

2022-04-24 价格：￥需询单马来酸阿伐曲波帕

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AKR 501

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