Atractylenolide II

产品详情：

发布时间： 2021-07-26 18:31:53

CAS号：73069-14-4

常用名： 白术内酯II；苍术内酯II

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese); anti-proliferative activity.IC50 value: 82.3 μM(B16 melanoma cell, 48 h) [1]Target: anticancer natural compoundin vitro: AT-II treatment for 48 h dose-dependently inhibited cell proliferation with an IC(50) of 82.3 μM, and induced G1 phase cell cycle arrest. Moreover, treatment with 75 μM AT-II induced apoptosis. These observations were associated with the decrease of the expression of Cdk2, phosphorylated-Akt, phosphorylated-ERK and Bcl-2, the increase of the expression of phosphorylated-p38, phosphorylated-p53, p21, p27, and activation of caspases-8, -9 and -3. In addition, a chemical inhibitor of p53, PFTα, significantly decreased AT-II-mediated growth inhibition and apoptosis [1]. In B16 and A375 cells, AT-II (20, 40 μm) treatment for 48 h dose-dependently reduced protein expression levels of phospho-STAT3, phospho-Src, as well as STAT3-regulated Mcl-1 and Bcl-xL. Overexpression of a constitutively active variant of STAT3, STAT3C in A375 cells diminished the antiproliferative and apoptotic effects of AT-II [2].in vivo: Daily administration of AT-II (12.5, 25 mg/kg, i.g.) for 14 days significantly inhibited tumor growth in a B16 xenograft mouse model and inhibited the activation/phosphorylation of STAT3 and Src in the xenografts [2]. 物理化学性质： CAS号：73069-14-4 常用中文名：白术内酯II；苍术内酯II 常用英文名：Atractylenolide II 分子式：C15H20O2 分子量：232.318 密度：1.1±0.1 g/cm3 沸点：378.0±41.0 °C at 760 mmHg 熔点：N/A 闪点：158.7±25.0 °C 储存条件：-20°C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

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地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2024-07-15 价格：需询单白术内酯Ⅱ

2024-09-29 价格：￥需询单 Atractylenolide II

2025-12-29 价格：￥需询单白术内酯II

2022-11-03 价格：￥960.0 白术内酯 II

2016-03-31 价格：￥950.0 白术内酯Ⅱ

2021-02-06 价格：￥2949.0 2-Atractylenolide

2024-03-06 价格：￥需询单白术内酯Ⅱ

2022-02-17 价格：￥350.0 白术内酯Ⅱ

2023-09-22 价格：￥需询单中药对照品白术内酯Ⅱ

2017-11-25 价格：￥需询单白术内酯II

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白术内酯II；苍术内酯II价格

Atractylenolide II

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