8,11,14-Eicosatriynoic Acid

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发布时间： 2021-07-26 18:31:33

CAS号：34262-64-1

常用名： 8,11,14-二十碳三烯酸

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： 8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandins, leukotriene biosynthesis and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenation The enzyme (COX) and 5-lipoxygenase (5-LO) IC50 values were 0.46 μM, 14 μM and 25 μM, respectively. In addition, it inhibits the action of slow-reacting substances of allergic reactions with IC50 values of 10 μM [1,2]. Lipoxygenase is widely found in fungi, plants and animals, and its content is very high. 12-LO is involved in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and various other NSAIDs, making them clinically important [3]. 5-LO is involved in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. In vitro: As of now, in vitro studies of 8,11,14-eicosatriynoic acid are still under development. In vivo: To date, in vivo studies of 8,11,14-eicosatriynoic acid are in the development stage. References: [1]. Goetz, J., Sprecher, H., Cornwell, D. and Panganamala, R . Inhibition of prostaglandin biosynthesis by triynoic acid. . prostaglandins. 1976;12(2):187-192. [2]. Sun, F., McGuire, J., Morton, D., Pike, J., Sprecher, H. and Kunau, W. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds effect. prostaglandins. 1981;21(2):333-343. [3]. Fitzpatrick, F. Cyclooxygenase: regulation and function. Current Drug Design. 2004;10(6):577-588. 物理化学性质： CAS号：34262-64-1 常用中文名：8,11,14-二十碳三烯酸常用英文名：8,11,14-Icosatriynoic acid 分子式：C20H28O2 分子量：300.435 密度：1.0±0.1 g/cm3 沸点：469.6±40.0 °C at 760 mmHg 熔点：N/A 闪点：220.4±22.0 °C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

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其他供应商价格：

2024-07-15 价格：需询单 8,11,14-Eicosatriynoic acid

2021-02-06 价格：￥1207.0 8,11,14-Eicosatriynoic Acid

2022-03-04 价格：￥4028.0 8,11,14-二十碳三烯酸

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8,11,14-二十碳三烯酸价格

8,11,14-Eicosatriynoic Acid

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