Doxapram hydrochloride monohydrate

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更新时间： 2023-02-23 09:19:50

CAS号：7081-53-0

常用名： 盐酸多沙普仑

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

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其他详情（用途，包装）：
用途： Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.Target: Potassium ChannelDoxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release of dopamine. Our results indicate that the mechanism of action of doxapram shares similarities with that of hypoxia in the carotid body [1]. Doxapram (1-100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the neuronal cell line NG-108 15, suggesting a selective effect on carotid body type I cells. The effects of doxapram on type I cells show similarities to those of the physiological stimuli of the carotid body, suggesting that doxapram may share a similar mechanism of action in stimulating the intact organ [2]. 物理化学性质： CAS号：7081-53-0 常用中文名：盐酸多沙普仑常用英文名：Doxapram (hydrochloride hydrate) 分子式：C24H33ClN2O3 分子量：432.983 密度：N/A 沸点：N/A 熔点：217-219° 闪点：N/A 储存条件：室温，干燥

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2025-09-17 价格：￥需询单盐酸多沙普仑一水合物

2021-02-06 价格：￥789.0 Doxapram HCl

2018-04-14 价格：￥需询单盐酸多沙普仑

2024-01-09 价格：$需询单 Doxapram hydrochloride monohydrate

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盐酸多沙普仑价格

Doxapram hydrochloride monohydrate

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