Tropisetronhydrochloride

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发布时间： 2021-07-26 18:31:53

CAS号：105826-92-4

常用名： 盐酸托烷司琼

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.IC50 value: 70.1 ± 0.9 nMTarget: 5-HT3 receptor; α7-nicotinic receptorin vitro: Retinal ganglion cells(RGCs) pretreated with 100 nM tropisetron before glutamate increased cell survival to an average of 105% compared to controls. Inhibition studies using the alpha7 nAChR antagonist, MLA (10 nM), support the hypothesis that tropisetron is an effective neuroprotective agent against glutamate-induced excitotoxicity; mediated by α7 nAChR activation. Tropisetron had no discernible effects on pAkt levels but significantly decreased p38 MAPK levels associated with excitotoxicity from an average of 15 ng/ml to 6 ng/ml [2]. Tropisetron, but not granisetron, significantly inhibits the phosphatase activity of calcineurin, over-expresses the CB(1) receptors at both transcriptional and protein levels, and reduces cAMP content in cerebellar granule neurons (CGNs) [4].in vivo: Animals were treated intracerebroventricularly with tropisetron, mCPBG (selective 5-HT3 receptor agonist) or mCPBG plus tropisetron on days 1, 3, 5 and 7. Tropisetron significantly diminished the elevated levels of these markers and reversed the cognitive deficit. Interestingly, tropisetron was also found to be a potent inhibitor of calcineurin phosphatase activity [1]. tropisetron (5mg/kg/day) plus mCPBG (10mg/kg/day), and granisetron (5mg/kg/day) intraperitoneally on days 3-35 post-immunization. Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p 物理化学性质： CAS号：105826-92-4 常用中文名：盐酸托烷司琼常用英文名：Tropisetron hydrochloride 分子式：C17H21ClN2O2 分子量：320.814 密度：N/A 沸点：448.5ºC at 760 mmHg 熔点：283-285ºC 闪点：225ºC 储存条件：2-8°C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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年贸易额：10 to 20 million USD

外贸占销售比例：90%

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2024-07-15 价格：需询单盐酸托烷司琼

2024-09-13 价格：￥需询单盐酸托烷司琼

2017-07-08 价格：￥需询单盐酸托烷司琼

2018-04-02 价格：￥需询单盐酸托烷司琼

2018-10-26 价格：￥需询单盐酸托烷司琼 105826-92-4

2021-02-06 价格：￥4269.0 Tropisetron

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盐酸托烷司琼价格

Tropisetronhydrochloride

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