Folinic acid

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更新时间： 2022-02-12 10:14:52

CAS号：58-05-9

常用名： 亚叶酸

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate.Target: AntifolateFolinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. In 1980s, however, folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists. Although the mechanism is not very clear, the polyglutamylation of methotrexate and dihydrofolate in malignant cells is considered to play an important role in the selective reactivation of dihydrofolate reductase by folinic acid in normal cells [1]. Folinic acid is generally administered along with MTX as a rescue agent to decrease MTX-induced toxicity. However, information regarding the inhibitory effect of folinic acid against cytogenetic damage caused by MTX is limited. This study was conducted to assess the cytogenetic effect of MTX and its inhibition by folinic acid (FA) using the micronucleus and chromosomal aberration assays concurrently [2]. 物理化学性质： CAS号：58-05-9 常用中文名：亚叶酸常用英文名：Folinic acid 分子式：C20H23N7O7 分子量：473.43900 密度：1.68g/cm3 沸点：N/A 熔点：245ºC (decomp) 闪点：N/A 储存条件：2-8℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

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联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2024-03-12 价格：￥3089.9 亚叶酸

2025-09-17 价格：￥需询单亚叶酸

2026-03-10 价格：￥需询单亚叶酸

2021-02-06 价格：￥489.0 Folinic acid

2024-01-09 价格：$需询单 5-formyltetrahydrofolic acid

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亚叶酸价格

Folinic acid

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