Doxifluridine

产品详情：

发布时间： 2021-07-26 18:31:53

CAS号：3094-09-5

常用名： 去氧氟尿苷

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Doxifluridine(Ro 21-9738; 5'-DFUR) is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM. IC50 value: 0.62 μM(PC9-DPE2 cell).Target: Nucleoside antimetabolite/analogDoxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.in vitro: 5'-DFUR's metabolic product(N3-Me-5'-dFUR) was found to be non-toxic in all the cell growth experiments performed. The absence of cytotoxicity could be explained by the observation that the metabolite was not recognized as a substrate by thymidine phosphorilase, the enzyme responsible for 5-fluorouracil (5-FU) release from doxifluridine, as ascertained by high-performance liquid chromatography/ultraviolet (HPLC-UV) analysis of the incubation mixture[1].in vivo: Administration of 200 mg of Furtulon to 23 beagle dogs, the plasma concentrations of doxifluridine, 5-FU, and 5-FUrd were measured simultaneously, using LC-MS/MS. The parent-metabolite compartment model with first-order absorption and Michaelis-Menten kinetics described the pharmacokinetics of doxifluridine, 5-FU, and 5-FUrd. Michaelis-Menten kinetics sufficiently explained the generation and elimination processes of 5-FU and 5-FUrd[2].Clinical trial: A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer was reported in 2009[3]. 物理化学性质： CAS号：3094-09-5 常用中文名：去氧氟尿苷常用英文名：Doxifluridine 分子式：C9H11FN2O5 分子量：246.192 密度：1.6±0.1 g/cm3 沸点：N/A 熔点：188-192 °C(lit.) 闪点：N/A 储存条件：-20°C Freezer

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2022-02-19 价格：￥43.9 5'-脱氧-5-氟尿苷

2016-11-01 价格：￥350.0 去氧氟尿苷

2022-03-22 价格：￥需询单去氧氟尿苷/氟铁龙

2018-02-27 价格：$需询单 5'-Deoxy-5-fluorouridine

2020-12-08 价格：￥509.0 去氧氟尿苷

2018-10-26 价格：￥需询单去氧氟尿苷 3094-09-5

2024-01-09 价格：$需询单 doxifluridine

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去氧氟尿苷价格

Doxifluridine

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