STING agonist-1

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更新时间： 2023-02-23 17:36:08

CAS号：702662-50-8

常用名： STING激动剂-1

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM). IC50 value: 24.57 μM (IC90)Target: VEEV, STINGin vitro: G10 does not bind to STING directly, however, G10 represents the first synthetic small molecule characterized as an indirect activator of human STING-dependent phenotypes.100 μM G10 (a concentration over twelve times the IC90 for CHIKV and over four times the IC90 for VEEV). G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 Induces IFN/IRF3- but not NF-κB-Dependent Transcription in Human Fibroblasts. G10 activates IRF3, but not canonical NF-κB pathways in human fibroblasts. G10 elicits antiviral activity against New and Old World Alphaviruses. G10 stimulates phosphorylation of IFN regulatory factor 3 (IRF3) in a manner similar to that triggered by UV-inactivated cytomegalovirus (UV-CMV) and Sendai virus (SeV). G10 induces synthesis and secretion of bioactive type I and III IFNs and generates an antiviral state in fibroblast cells positive for STING, IRF3, and STAT1 proteins. G10 triggers innate immune responses that involve expression of IRF3-dependent genes including type I and III interferons. 物理化学性质： CAS号：702662-50-8 常用中文名：STING激动剂-1 常用英文名：G10, STING signaling activator 分子式：C21H16ClFN2O3S 分子量：430.880 密度：1.4±0.1 g/cm3 沸点：668.3±55.0 °C at 760 mmHg 熔点：N/A 闪点：358.0±31.5 °C 储存条件：2-8℃

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2022-03-04 价格：￥308.9 G10, STING signaling activator

2024-07-15 价格：需询单 STINGagonist-1

2021-02-06 价格：￥4609.0 STING agonist-1

2022-05-12 价格：$需询单 STING agonist-1

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STING激动剂-1价格

STING agonist-1

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